胆红素可引起牙齿变色和牙髓缺损

IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pediatric Dental Journal Pub Date : 2022-04-01 DOI:10.1016/j.pdj.2021.11.002

Haruyoshi Yamaza

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引用次数: 0

摘要

背景系统因素和局部因素对牙形成和牙出牙后的牙齿有不同的影响。牙齿变色也是由系统和局部因素引起的，有时会导致美学和生物学问题。胆红素是血红素代谢的产物，在血液中浓度高，可引起发绿和下颌畸形。目的利用人脱落乳牙(SHED)干细胞体外模型研究胆红素对牙形成的影响。结果近年来的研究表明，胆红素通过改变细胞相关信号通路抑制细胞增殖，促进细胞死亡。此外，研究表明帕米膦酸盐恢复了胆红素改变的信号通路和胆红素损伤的SHED牙本质功能。结论shed可作为建立人体外模型、阐明人发病机制和筛选候选药物的工具。

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Bilirubin induces discoloration and hypodontia on tooth

Background

Systematic and local factors give various effects to teeth during odontogenesis or after eruption. Discoloration of teeth is also caused by systematic and local factors and sometimes leads to esthetic and biological problems. Bilirubin is the product of heme metabolism and causes greenish discoloration and hypodontia with its high concentration in blood.

Objective

This review aimed to indicate effects of bilirubin on odontogenesis with in vitro model established by stem cells of human exfoliated deciduous teeth (SHED).

Results

Recent studies showed that bilirubin suppressed cell proliferation and promoted cell death in SHED with alteration of their involved-signaling pathways. In addition, it was indicated that pamidronate recovered bilirubin-altered signaling pathways and bilirubin-impaired dentinogenic function of SHED.