基于磁示踪技术的胃肿瘤定位实验研究

Qian Fan, Yi Lin, Jia Ma, Senlin Zhu, Yu-wei Wu, Xingyi Mou, Bo Deng, Shiran Kang, Fan Min, Feng Ma, Y. Lyu, Xiaopeng Yan
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引用次数: 1

摘要

目的验证基于磁示踪技术的胃肿瘤标志物在犬体内定位的可行性和安全性。方法对6只比格犬进行胃镜检查。然后将示踪磁体发送到预先假设的“肿瘤”位置,并通过内窥镜软组织夹固定在“肿瘤”附近。24小时后在全麻下进行腹腔镜胃肿瘤定位。在常规建立腹腔镜穿刺平行镜后,通过手术孔将示踪磁体放置在胃表面肿瘤附近,以探索示踪磁体。吸引两块磁铁后,在腹腔镜下看到的示踪磁铁的位置就是胃肿瘤的位置,从而完成病变的标记和定位。结果6只比格犬均在胃镜下成功植入示踪磁铁,胃镜检查24小时后,在腹腔镜手术中成功植入追踪磁铁。两块磁铁自动相互吸引,形成“示踪磁铁胃壁追踪磁铁”的三明治结构,完成了腹腔镜下胃肿瘤的定位和识别。结论基于磁示踪技术的胃镜结合腹腔镜检查方法简单、准确、安全、可行。关键词:胃肿瘤;磁小体;胃镜;腹腔镜检查
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Experimental study of stomach tumor localization based on magnetic tracer technique
Objective To verify the feasibility and safety of stomach tumor marker localization based on magnetic tracer technique in dogs. Methods Six male Beagle dogs were examined by gastroscopy. Then tracer magnets were sent to the "tumor" locations assumed in advance and fixed near the "tumors" by endoscopic soft tissue clamp. Laparoscopic gastric tumor localization was performed under general anesthesia 24 hours later. The tracer magnet was placed near the tumor on the surface of the stomach through the operating hole after the conventional establishment of laparoscope puncture parallel mirror to explore the tracer magnet. After the two magnets were attracted, the location of the tracer magnet seen under the laparoscope was the location of the gastric tumor, so as to complete the labeling and positioning of the lesion. Results All the 6 Beagle dogs were successfully implanted with tracer magnets under gastroscopy .Twenty-four hours after the gastroscopy, the pursuit magnet was successfully implanted during laparoscopic surgery. The two magnets automatically attracted each other and formed a sandwich structure of "tracer magnet-gastric wall-pursuit magnet" , which completed the location and identification of gastric tumor under the laparoscopy. Conclusion Gastroscopy combined with laparoscopy based on magnetic tracer technique is simple, accurate, safe and feasible. Key words: Stomach neoplasms; Magnetosomes; Gastroscopes; Laparoscopy
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