Laryngeal Amyloidosis Case Series: Rare Cause of Hoarseness

Background: Amyloidosis is defined as a group of diseases which resulted from abnormal extracellular deposition of insoluble protein, called amyloid. It can either presented as localized or with systemic involvement. Laryngeal amyloidosis is a very rare cause of dysphonia, accounting for only 0.2 to 1.2 percent of all benign laryngeal tumours. Objectives: To highlight the clinical presentations and raise awareness of laryngeal amyloidosis among otorhinolaryngology surgeons. An index of suspicion must be conveyed to the histopathologist in the request form for them to embark on a specific staining technique. Method: We discussed two cases of laryngeal amyloidosis, with their presentations, management and the follow up. Both cases were middle aged female. The diagnosis of laryngeal amyloidosis is only by histopathological as clinically it is very ambiguous. Conclusion: The mainstay of treatment for laryngeal amyloidosis is surgical debulking but it is not curative as complete removal of the diseased tissue is difficult. In addition, the treatment should be directed towards the maintenance of the airway and the improvement of the voice.