豚鼠B细胞淋巴细胞白血病一例报告

IF 0.6 4区农林科学 Q3 VETERINARY SCIENCES Acta Veterinaria Brno Pub Date : 2021-07-17 DOI:10.2754/avb202190020221

M. Levkut, P. Major, L. Kottferová, M. Levkut

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引用次数: 1

摘要

在这个病例报告中，描述了一个五岁的雌性豚鼠的淋巴细胞白血病。临床检查显示淋巴结病变，主要表现为腘窝淋巴结增大。血液学检测淋巴母细胞。尸检结果为肝、脾肿大。肝、脾、淋巴结组织病理学检查显示肿瘤细胞为淋巴母细胞型。这些细胞表现出相当大的细胞多形性。免疫组织化学法对蛋白标记物CD3、CD20和配对盒5 (PAX5)转录因子进行追踪。PAX5免疫表型显示该标记物的核阳性，但CD3和CD20(豚鼠没有种间交叉反应)在肿瘤细胞中未显示阳性反应。cd3阳性细胞仅在作为对照的豚鼠组织切片中发现。在豚鼠中，PAX5似乎是b细胞源性肿瘤的有益和首选标记物。

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B-cell lymphoblastic leukaemia in a guinea-pig – a case report

In this case report, lymphoblastic leukaemia is described in a five-year-old female guinea pig. Clinical examination revealed lymphadenopathy, mainly with increased size of the popliteal lymph nodes. Lymphoblast cells were determined haematologically. Postmortem findings were hepatomegaly and splenomegaly. Histopathological examination of liver, spleen and lymph nodes revealed tumour cells of lymphoblastic type. These cells showed considerable cellular pleomorphism. The protein markers CD3 and CD20 and paired box 5 (PAX5) transcription factor were traced immunohistochemically. Immunophenotypization using PAX5 showed nuclear positivity of this marker, but CD3 and CD20 (not interspecies cross-reactivity for guinea pig) demonstrated no positive reaction in the tumour cells. CD3-positive cells were found only in guinea pig tissue sections used as control. PAX5 in guinea pigs appears as a beneficial and preferred marker for B-cell derived tumours.

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来源期刊

Acta Veterinaria Brno 农林科学-兽医学

CiteScore

1.00

自引率

33.30%

发文量

审稿时长

18-36 weeks

期刊介绍： ACTA VETERINARIA BRNO is a scientific journal of the University of Veterinary and Pharmaceutical Sciences in Brno, Czech Republic. The scientific journal Acta Veterinaria Brno is dedicated to the publication of original research findings and clinical observations in veterinary and biomedical sciences. Original scientific research articles reporting new and substantial contribution to veterinary science and original methods that have not been submitted for publication elsewhere are considered for publication. A written statement to this effect should accompany the manuscript, along with approval for publication by the author´s head of department. The authors bear full responsibility for the contents of their contribution. Book reviews are published, too.