{"title":"内皮细胞蛋白C受体在造血干细胞中的作用","authors":"Xiyan Wang","doi":"10.3760/CMA.J.ISSN.1673-419X.2019.03.015","DOIUrl":null,"url":null,"abstract":"Endothelial protein C receptor (EPCR) is one of the components of protein C anticoagulation system, which has important significance in anticoagulation regulation and cell protection. It has been found that EPCR is one of the surface markers of hematopoietic stem cells (HSC) and can be used for sorting and purification of HSC. EPCR can participate in the regulation of HSC and its microenvironment through protease-activated receptor (PAR)1 signaling and other pathways, and it can mediate the retention and hematopoietic function reconstitution of HSC in bone marrow. This article intends to review the application of EPCR in HSC sorting and purification, as well as the research progress of EPCR on the regulation of HSC and its related mechanisms. \n \n \nKey words: \nEndothelial cells; Hematopoietic stem cells; Protease activated receptor 1; Endothelial protein C receptor; Protein C; Activated protein C","PeriodicalId":13774,"journal":{"name":"国际输血及血液学杂志","volume":"42 1","pages":"259-263"},"PeriodicalIF":0.0000,"publicationDate":"2019-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Role of endothelial cell protein C receptor in hematopoietic stem cells\",\"authors\":\"Xiyan Wang\",\"doi\":\"10.3760/CMA.J.ISSN.1673-419X.2019.03.015\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Endothelial protein C receptor (EPCR) is one of the components of protein C anticoagulation system, which has important significance in anticoagulation regulation and cell protection. It has been found that EPCR is one of the surface markers of hematopoietic stem cells (HSC) and can be used for sorting and purification of HSC. EPCR can participate in the regulation of HSC and its microenvironment through protease-activated receptor (PAR)1 signaling and other pathways, and it can mediate the retention and hematopoietic function reconstitution of HSC in bone marrow. This article intends to review the application of EPCR in HSC sorting and purification, as well as the research progress of EPCR on the regulation of HSC and its related mechanisms. \\n \\n \\nKey words: \\nEndothelial cells; Hematopoietic stem cells; Protease activated receptor 1; Endothelial protein C receptor; Protein C; Activated protein C\",\"PeriodicalId\":13774,\"journal\":{\"name\":\"国际输血及血液学杂志\",\"volume\":\"42 1\",\"pages\":\"259-263\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-05-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"国际输血及血液学杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.1673-419X.2019.03.015\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"国际输血及血液学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1673-419X.2019.03.015","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Role of endothelial cell protein C receptor in hematopoietic stem cells
Endothelial protein C receptor (EPCR) is one of the components of protein C anticoagulation system, which has important significance in anticoagulation regulation and cell protection. It has been found that EPCR is one of the surface markers of hematopoietic stem cells (HSC) and can be used for sorting and purification of HSC. EPCR can participate in the regulation of HSC and its microenvironment through protease-activated receptor (PAR)1 signaling and other pathways, and it can mediate the retention and hematopoietic function reconstitution of HSC in bone marrow. This article intends to review the application of EPCR in HSC sorting and purification, as well as the research progress of EPCR on the regulation of HSC and its related mechanisms.
Key words:
Endothelial cells; Hematopoietic stem cells; Protease activated receptor 1; Endothelial protein C receptor; Protein C; Activated protein C
期刊介绍：
The International Journal of Transfusion and Hematology was founded in September 1978. It is a comprehensive academic journal in the field of transfusion and hematology, supervised by the National Health Commission and co-sponsored by the Chinese Medical Association, West China Second Hospital of Sichuan University, and the Institute of Transfusion Medicine of the Chinese Academy of Medical Sciences. The journal is a comprehensive academic journal that combines the basic and clinical aspects of transfusion and hematology and is publicly distributed at home and abroad. The International Journal of Transfusion and Hematology mainly reports on the basic and clinical scientific research results and progress in the field of transfusion and hematology, new experiences, new methods, and new technologies in clinical diagnosis and treatment, introduces domestic and foreign research trends, conducts academic exchanges, and promotes the development of basic and clinical research in the field of transfusion and hematology.
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