基于动脉灌注的局部转移性皮肤和葡萄膜黑色素瘤治疗

IF 1 Q4 ONCOLOGY Melanoma Management Pub Date : 2019-09-02 DOI:10.2217/mmt-2019-0006

Kristy K Broman, Jonathan S Zager

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引用次数: 0

摘要

区域性疾病在皮肤黑色素瘤和葡萄膜黑色素瘤中仍然是一个具有挑战性的问题。基于动脉的化学灌注策略能够以最小的全身毒性进行区域治疗。在此，我们讨论了动脉内治疗在途四肢皮肤黑色素瘤的方法，包括高温离体肢体灌注和离体肢体输注。我们还讨论了葡萄膜黑色素瘤孤立性肝转移的开放（孤立性肝灌注）和经皮肝灌注技术。我们综述了局部黑色素瘤转移的动脉内化学灌注的适应症、手术技术、结果和预期毒性方面的知识现状。

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Intra-arterial perfusion-based therapies for regionally metastatic cutaneous and uveal melanoma.

Locoregional disease remains a challenging problem in cutaneous melanoma and uveal melanoma. Arterial-based chemoperfusion strategies enable regional therapy delivery with minimal systemic toxicity. Herein we discuss intra-arterial therapies for in-transit cutaneous melanoma of the extremity including hyperthermic-isolated limb perfusion and isolated limb infusion. We also discuss open (isolated hepatic perfusion) and percutaneous hepatic perfusion techniques for isolated liver metastases from uveal melanoma. We review the current state of knowledge with respect to indications, procedural techniques, outcomes and expected toxicities for intra-arterial chemoperfusion for locoregional melanoma metastases.

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来源期刊

Melanoma Management ONCOLOGY-

CiteScore

5.10

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： Skin cancer is on the rise. According to the World Health Organization, 132,000 melanoma skin cancers occur globally each year. While early-stage melanoma is usually relatively easy to treat, once disease spreads prognosis worsens considerably. Therefore, research into combating advanced-stage melanoma is a high priority. New and emerging therapies, such as monoclonal antibodies, B-RAF and KIT inhibitors, antiangiogenic agents and novel chemotherapy approaches hold promise for prolonging survival, but the search for a cure is ongoing. Melanoma Management publishes high-quality peer-reviewed articles on all aspects of melanoma, from prevention to diagnosis and from treatment of early-stage disease to late-stage melanoma and metastasis. The journal presents the latest research findings in melanoma research and treatment, together with authoritative reviews, cutting-edge editorials and perspectives that highlight hot topics and controversy in the field. Independent drug evaluations assess newly approved medications and their role in clinical practice. Key topics covered include: Risk factors, prevention and sun safety education Diagnosis, staging and grading Surgical excision of melanoma lesions Sentinel lymph node biopsy Biological therapies, including immunotherapy and vaccination Novel chemotherapy options Treatment of metastasis Prevention of recurrence Patient care and quality of life.