自闭症谱系障碍患者的健康状况

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2021-08-23 DOI:10.1108/aia-01-2021-0005
Antonio Koceski, Vladimir Trajkovski
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引用次数: 1

摘要

目的本研究的目的是确定与神经正常对照组相比,自闭症谱系障碍(ASD)患者的健康状况发生了哪些变化。设计/方法/方法作者对72名ASD受试者和75名年龄在3-24岁的神经正常对照者的数据进行了比较分析 罗切斯特健康状况调查IV(RHSS-IV)。进行了一次结构化的个人访谈,以比较马其顿受试者的健康状况。发现与神经正常人群相比,大多数ASD患者服用维生素、补充剂并使用推荐的药物治疗,并出现大量副作用(p=0.000)。与神经正常发育的人相比,ASD儿童口腔溃疡的患病率更高(31.9%对17.3%;p=0.039),神经健康状况的变化——癫痫(19.4%vs 2.7%;p=0.001)和ADD/ADHD(仅ASD-19.4%;p=0.000);呼吸系统疾病-心绞痛(30.5%vs 8%;p=0.000)、鼻炎和/或鼻窦炎(40.3%vs 17.3%;p=0.02);胃肠道系统的变化——便秘(31.9%vs10.6%;p=0.02)、肠道炎症(19.4%vs8%;p=0.043)、可渗透性肠道(仅ASD患者为13.9%;p=0.000)和真菌白色念珠菌的存在(19.4%vs 4%;p=0.043);精神障碍-睡眠问题(仅在ASD患者中为18%;p=0.000)和抽搐(6.9%vs 2.6%;p=0.025)以及皮肤病-湿疹/过敏性皮疹(36.1%vs 18.7%;p=0.02)。独创性/价值许多ASD儿童都有健康问题。这些发现支持并补充了关于它们相互因果关系的专业文献。
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Health status of people with autism spectrum disorder
Purpose The aim of this study is to determine what changes occur in the health status of people with autism spectrum disorder (ASD) compared to neurotypical controls. Design/methodology/approach The authors performed a comparative analysis of data collected from 72 subjects with ASD and 75 neurotypical controls aged 3–24 years using the Rochester Health Status Survey IV (RHSS-IV). A structured individual interview was conducted to compare the health status of subjects in Macedonia. Findings A majority of people with ASD take vitamins, supplements and use recommended drug therapies compared to the neurotypical population and experience a larger number of side effects (p = 0.000). Compared to people with neurotypical development, children with ASD have a higher prevalence of oral ulcers (31.9% vs 17.3%; p = 0.039), changes in neurological health status – epilepsy (19.4% vs 2.7%; p = 0.001) and ADD/ADHD (only persons with ASD-19.4%; p = 0.000); respiratory diseases – angina (30.5% vs 8%; p = 0.000), rhinitis and/or sinusitis (40.3% vs 17.3%; p = 0.02); changes in the gastrointestinal system – constipation (31.9% vs 10.6%; p = 0.02), intestinal inflammation (19.4% vs 8%; p = 0.043), permeable intestines (only persons with ASD – 13.9%; p = 0.000) and the presence of the fungus Candida albicans (19.4% vs 4%; p = 0.043); psychiatric disorders – sleep problems (only in people with ASD – 18%; p = 0.000) and tics (6.9% vs 2.6%; p = 0.25) and skin diseases – eczema/allergic skin rash (36.1% vs 18.7%; p = 0.02). Originality/value Many children with ASD have health problems. These findings support and complement the professional literature on their mutual causality.
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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