原发性高血压患者血浆和尿神经生长因子水平升高

IF 1.9 4区 医学 Q3 PERIPHERAL VASCULAR DISEASE International Journal of Hypertension Pub Date : 2022-03-01 DOI:10.1155/2022/3003269
F. Tomoda, A. Nitta, H. Sugimori, T. Koike, K. Kinugawa
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引用次数: 1

摘要

神经生长因子(NGF)是控制心血管器官交感神经支配和交感神经活动的主要神经营养因子。尽管NGF的过度产生及其对交感神经系统的影响已在高血压动物中得到证实,但NGF的状态及其与交感神经活动的关系尚未在人类高血压中得到探索。因此,在本研究中,比较了83名未经治疗且无明显心血管损伤的原发性高血压患者和81名血压正常的健康受试者的血浆和尿液NGF水平以及儿茶酚胺水平(即分别为NGF状态和交感肾上腺活动指数)。高血压组的血浆和尿液NGF水平显著升高(311 ± 158 pg/mL和72.7 ± 54 ng/g Cr)高于血压正常组(168 ± 188 pg/mL和54.5 ± 38.8 ng/g Cr)(每次测量均p<0.05),即使调整了组间年龄和性别的基线差异。同样,除血浆去甲肾上腺素外,高血压组的血浆和尿液儿茶酚胺水平显著高于血压正常组。此外,尽管两组血浆NGF和儿茶酚胺水平之间没有显著相关性,但高血压组尿NGF与尿去甲肾上腺素和尿肾上腺素均呈正相关(r = 0.259,p=0.018,r = 0.232,p=0.035),但在血压正常的组中没有(r = 0.115,p=0.307,r = −0.018,p=0.871)。相反,两组的血浆和尿液NGF水平以及儿茶酚胺水平与任何系统血液动力学指标(如血压和脉搏率)无关。因此,原发性高血压的特点是NGF状态和交感肾上腺活动增强,两者之间存在正相关。我们的数据表明,原发性高血压可能发生NGF状态增强和随后NGF诱导的交感神经-肾上腺过度活动。
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Plasma and Urinary Levels of Nerve Growth Factor Are Elevated in Primary Hypertension
Nerve growth factor (NGF) is the main neurotrophic factor that can control sympathetic nerve innervation and sympathetic neural activity in cardiovascular organs. Although NGF overproduction and its influences on the sympathetic nervous system have been shown in hypertensive animals, NGF status and its association with sympathetic nerve activity have not yet been explored in human hypertension. In the present study, therefore, plasma and urinary levels of NGF and those of catecholamines (i.e., indices for NGF status and sympathoadrenal activity, respectively) were compared between 83 untreated primary hypertensives without apparent cardiovascular damages and 81 healthy normotensive subjects. Plasma and urinary levels of NGF were significantly greater in the hypertensive group (311 ± 158 pg/mL and 72.7 ± 54.0 ng/g of Cr) than in the normotensive group (168 ± 188 pg/mL and 54.5 ± 38.8 ng/g of Cr) (p < 0.05 for each measurement), even if the baseline differences of age and gender between the groups were adjusted. Similarly, plasma and urinary levels of catecholamines were significantly higher in the hypertensive group than in the normotensive group except for plasma noradrenaline. In addition, despite no significant correlations between plasma levels of NGF and catecholamines in both groups, urinary NGF significantly correlated positively with both urinary noradrenaline and urinary adrenaline in the hypertensive group (r = 0.259, p=0.018 and r = 0.232, p=0.035), but not in the normotensive group (r = 0.115, p=0.307 and r = −0.018, p=0.871). On the contrary, plasma and urinary levels of NGF as well as those of catecholamines did not associate with any systemic hemodynamic indices such as blood pressure and pulse rate in either group. Thus, primary hypertension was characterized by the enhancements of both NGF status and sympathoadrenal activity and the positive relationship between them. Our data indicate that enhanced NGF status and subsequent NGF-induced sympathoadrenal overactivity could occur in primary hypertension.
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来源期刊
International Journal of Hypertension
International Journal of Hypertension Medicine-Internal Medicine
CiteScore
4.00
自引率
5.30%
发文量
45
期刊介绍: International Journal of Hypertension is a peer-reviewed, Open Access journal that provides a forum for clinicians and basic scientists interested in blood pressure regulation and pathophysiology, as well as treatment and prevention of hypertension. The journal publishes original research articles, review articles, and clinical studies on the etiology and risk factors of hypertension, with a special focus on vascular biology, epidemiology, pediatric hypertension, and hypertensive nephropathy.
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