{"title":"亚临界水中过氧化氢对氢氯噻嗪的矿化作用","authors":"Erdal Yabalak, Özkan Görmez, Yahya Nural","doi":"10.18596/jotcsa.449979","DOIUrl":null,"url":null,"abstract":"In this paper, we investigated the mineralization of hydrochlorothiazide, a diuretic drug which is used for the treatment of hypertension, using H 2 O 2 as the oxidizing agent in subcritical water as a medium. Response surface methodology was applied to optimize experimental parameters such as temperature, treatment time, and concentration of the oxidizing agent. 85.22% of TOC removal was obtained at 403 K, 80 mM of hydrogen peroxide and 147.3 min. The reliability of the performed method was evaluated by ANOVA and the theoretical equation of TOC removal of hydrochlorothiazide was proposed. F and p values of the model were determined as 62.88 and lower than 0.0001, respectively.","PeriodicalId":17402,"journal":{"name":"Journal of the Turkish Chemical Society, Section A: Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Mineralization of Hydrochlorothiazide using Hydrogen Peroxide in Subcritical Water\",\"authors\":\"Erdal Yabalak, Özkan Görmez, Yahya Nural\",\"doi\":\"10.18596/jotcsa.449979\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In this paper, we investigated the mineralization of hydrochlorothiazide, a diuretic drug which is used for the treatment of hypertension, using H 2 O 2 as the oxidizing agent in subcritical water as a medium. Response surface methodology was applied to optimize experimental parameters such as temperature, treatment time, and concentration of the oxidizing agent. 85.22% of TOC removal was obtained at 403 K, 80 mM of hydrogen peroxide and 147.3 min. The reliability of the performed method was evaluated by ANOVA and the theoretical equation of TOC removal of hydrochlorothiazide was proposed. F and p values of the model were determined as 62.88 and lower than 0.0001, respectively.\",\"PeriodicalId\":17402,\"journal\":{\"name\":\"Journal of the Turkish Chemical Society, Section A: Chemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the Turkish Chemical Society, Section A: Chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.18596/jotcsa.449979\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Chemistry\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Turkish Chemical Society, Section A: Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18596/jotcsa.449979","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Chemistry","Score":null,"Total":0}
Mineralization of Hydrochlorothiazide using Hydrogen Peroxide in Subcritical Water
In this paper, we investigated the mineralization of hydrochlorothiazide, a diuretic drug which is used for the treatment of hypertension, using H 2 O 2 as the oxidizing agent in subcritical water as a medium. Response surface methodology was applied to optimize experimental parameters such as temperature, treatment time, and concentration of the oxidizing agent. 85.22% of TOC removal was obtained at 403 K, 80 mM of hydrogen peroxide and 147.3 min. The reliability of the performed method was evaluated by ANOVA and the theoretical equation of TOC removal of hydrochlorothiazide was proposed. F and p values of the model were determined as 62.88 and lower than 0.0001, respectively.
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