肉鸡口服林可霉素和粘菌素联合用药后停药时间的确定

IF 3.8 3区农林科学 Q1 VETERINARY SCIENCES Pakistan Veterinary Journal Pub Date : 2020-04-01 DOI:10.29261/pakvetj/2019.115

N. Park

{"title":"肉鸡口服林可霉素和粘菌素联合用药后停药时间的确定","authors":"N. Park","doi":"10.29261/pakvetj/2019.115","DOIUrl":null,"url":null,"abstract":"Received: Revised: Accepted: Published online: August 22, 2019 October 18, 2019 October 25, 2019 November 06, 2019 The combination of lincomycin and colistin is widely used in poultry either for the prevention and treatment of bacterial infection or as additive. However, the presence of antimicrobial residues in food of animal origin is considered as threat to human health. Therefore, this study determined the withdrawal time (WT) by analyzing the residual concentration in tissues to overcome this problem. A combination product of lincomycin and colistin was administered to chickens. Antibiotic residues in edible tissues at different time-intervals were quantified using ELISA and chromatographic methods, and WT was determined. Antibiotics residues were high in the liver and kidney but were lower than the MRL on day 1 and rapidly decreased from day 3. The WT in the kidney was calculated as 2.95 days and is rounded off to 3 days. This study suggested the withdrawal time of 3 days as a precautionary principle for public health. ©2019 PVJ. All rights reserved","PeriodicalId":19845,"journal":{"name":"Pakistan Veterinary Journal","volume":" ","pages":""},"PeriodicalIF":3.8000,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Establishment of Withdrawal Period after Oral Administration of Lincomycin and Colistin Combination in Broiler Chicken\",\"authors\":\"N. Park\",\"doi\":\"10.29261/pakvetj/2019.115\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Received: Revised: Accepted: Published online: August 22, 2019 October 18, 2019 October 25, 2019 November 06, 2019 The combination of lincomycin and colistin is widely used in poultry either for the prevention and treatment of bacterial infection or as additive. However, the presence of antimicrobial residues in food of animal origin is considered as threat to human health. Therefore, this study determined the withdrawal time (WT) by analyzing the residual concentration in tissues to overcome this problem. A combination product of lincomycin and colistin was administered to chickens. Antibiotic residues in edible tissues at different time-intervals were quantified using ELISA and chromatographic methods, and WT was determined. Antibiotics residues were high in the liver and kidney but were lower than the MRL on day 1 and rapidly decreased from day 3. The WT in the kidney was calculated as 2.95 days and is rounded off to 3 days. This study suggested the withdrawal time of 3 days as a precautionary principle for public health. ©2019 PVJ. All rights reserved\",\"PeriodicalId\":19845,\"journal\":{\"name\":\"Pakistan Veterinary Journal\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2020-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pakistan Veterinary Journal\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.29261/pakvetj/2019.115\",\"RegionNum\":3,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pakistan Veterinary Journal","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.29261/pakvetj/2019.115","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}

引用次数: 0

摘要

收到：修订：接受：在线发布：2019年8月22日2019年10月18日2019年十月25日2019年11月06日林可霉素和粘菌素的组合在家禽中广泛用于预防和治疗细菌感染或作为添加剂。然而，动物源性食品中存在的抗微生物残留物被认为是对人类健康的威胁。因此，本研究通过分析组织中的残留浓度来确定停药时间（WT），以克服这一问题。林可霉素和粘菌素的组合产品被用于鸡。使用ELISA和色谱法对不同时间间隔的可食用组织中的抗生素残留量进行定量，并测定WT。肝脏和肾脏中的抗生素残留量较高，但在第1天低于MRL，并从第3天起迅速下降。肾脏中的WT计算为2.95天，四舍五入为3天。这项研究建议将3天的停药时间作为公众健康的预防原则。©2019 PVJ。保留所有权利

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Establishment of Withdrawal Period after Oral Administration of Lincomycin and Colistin Combination in Broiler Chicken

Received: Revised: Accepted: Published online: August 22, 2019 October 18, 2019 October 25, 2019 November 06, 2019 The combination of lincomycin and colistin is widely used in poultry either for the prevention and treatment of bacterial infection or as additive. However, the presence of antimicrobial residues in food of animal origin is considered as threat to human health. Therefore, this study determined the withdrawal time (WT) by analyzing the residual concentration in tissues to overcome this problem. A combination product of lincomycin and colistin was administered to chickens. Antibiotic residues in edible tissues at different time-intervals were quantified using ELISA and chromatographic methods, and WT was determined. Antibiotics residues were high in the liver and kidney but were lower than the MRL on day 1 and rapidly decreased from day 3. The WT in the kidney was calculated as 2.95 days and is rounded off to 3 days. This study suggested the withdrawal time of 3 days as a precautionary principle for public health. ©2019 PVJ. All rights reserved

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Pakistan Veterinary Journal 兽医-兽医学

CiteScore

4.20

自引率

13.00%

发文量

审稿时长

4-8 weeks

期刊介绍： The Pakistan Veterinary Journal (Pak Vet J), a quarterly publication, is being published regularly since 1981 by the Faculty of Veterinary Science, University of Agriculture, Faisalabad, Pakistan. It publishes original research manuscripts and review articles on health and diseases of animals including its various aspects like pathology, microbiology, pharmacology, parasitology and its treatment. The “Pak Vet J” (www.pvj.com.pk) is included in Science Citation Index Expended and has got 1.217 impact factor in JCR 2017. Among Veterinary Science Journals of the world (136), “Pak Vet J” has been i) ranked at 75th position and ii) placed Q2 in Quartile in Category. The journal is read, abstracted and indexed internationally.