髓系抑制细胞在肝病中作用的研究进展

IF 4.1 4区 医学 Q2 IMMUNOLOGY Scandinavian Journal of Immunology Pub Date : 2023-10-01 Epub Date: 2023-08-08 DOI:10.1111/sji.13312
Qianqian Sun, Heng Dai, Siliang Wang, Yuanyuan Chen, Huilian Shi
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引用次数: 0

摘要

骨髓来源的抑制细胞(MDSCs)是指一组在病理条件下激活后具有强大免疫抑制能力的未成熟骨髓细胞。由于其强大的免疫抑制能力,MDSCs在过去几年中在肿瘤学、感染、慢性炎症和自身免疫性疾病领域引起了广泛关注。MDSCs在肝脏疾病中的研究逐渐增多,其潜在的治疗作用将进一步探索。这篇综述综述了MDSCs在肝病中的参与和作用,从而确定了其治疗肝病的潜在靶点,并为肝病相关研究提供了新的方向。
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Progress in research on the role played by myeloid-derived suppressor cells in liver diseases.

Myeloid-derived suppressor cells (MDSCs) refer to a group of immature myeloid cells with potent immunosuppressive capacity upon activation by pathological conditions. Because of their potent immunosuppressive ability, MDSCs have garnered extensive attention in the past few years in the fields of oncology, infection, chronic inflammation and autoimmune diseases. Research on MDSCs in liver diseases has gradually increased, and their potential therapeutic roles will be further explored. This review presents a summary of the involvement and the role played by MDSCs in liver diseases, thus identifying their potential targets for the treatment of liver diseases and providing new directions for liver disease-related research.

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来源期刊
CiteScore
7.70
自引率
5.40%
发文量
109
审稿时长
1 months
期刊介绍: This peer-reviewed international journal publishes original articles and reviews on all aspects of basic, translational and clinical immunology. The journal aims to provide high quality service to authors, and high quality articles for readers. The journal accepts for publication material from investigators all over the world, which makes a significant contribution to basic, translational and clinical immunology.
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