红细胞回收系统在髋臼开放性手术中的应用效果

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2022-06-02 DOI:10.1155/2022/8276065
S. MacDonald, C. Byrd, E. Barlow, V. Nahar, J. Martin, D. Krenk
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引用次数: 0

摘要

在过去的50年里,移位髋臼骨折的治疗已经从卧床的保守治疗转向手术干预,以实现解剖复位、稳定固定并允许髋关节早期活动。然而,手术固定并非没有并发症。外伤性髋臼骨折的内固定术在受伤和手术时都伴随着大量的失血。这通常导致对同种异体血液制品的需求,这与发病率的增加有关(Vamvakas和Blajchman,2009)。为了避免与同种异体输血相关的风险,已经设计了许多技术和方法。红细胞抢救(CS)是一种术中血液抢救工具,从手术现场采集血液。它被清洗以去除血浆、白细胞和血小板。将红细胞重悬于晶体溶液中。如果重悬的红细胞的红细胞压积足够,则通过静脉输注给患者。CS在脊柱大手术、双侧膝关节置换术和髋关节翻修手术中的益处已得到充分证实(Goulet等人1989,Gee等人2011,Canan等人2013)。然而,文献综述了细胞保护器在骨科创伤手术中的应用,特别是髋臼手术,是有限的。我们研究所在一级创伤中心对63例连续手术的髋臼骨折进行了回顾性分析。我们的研究表明,失血量小于400的患者 mL接受自体血的可能性降低13倍,血红蛋白低于10.5的患者接受自体输血的可能性降低5倍(p<0.05)。我们还发现,没有血红蛋白水平低于10.5和EBL低于400的患者 mL接受自体回血。自体输血对同种异体输血量和输血率没有影响。我们认为,如果患者术前血红蛋白低于10.5或预期失血量低于400 mL,那么CS在术前血液保护策略中的作用应该非常有限(如果有的话)。我们发现ASA大于2、BMI大于24以及相关的骨折类型是高失血的危险因素。
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Efficacy of Red Cell Salvage Systems in Open Acetabular Surgery
Over the past 50 years, treatment of displaced acetabular fractures has moved away from conservative treatment with bedrest to operative intervention to achieve anatomic reduction, stable fixation, and allow early range of motion of the hip. However, operative fixation is not without complications. Internal fixation of traumatic acetabular fractures has been coupled with large volume of blood loss both at the time of injury and surgery. This often results in the need for allogenic blood products, which has been linked to increase morbidity (Vamvakas and Blajchman, 2009). In an attempt to avoid the risk associated with allogenic blood transfusion numerous techniques and methods have been devised. Red blood cell salvage (CS) is an intraoperative blood salvage tool where blood is harvested from the operative field. It is washed to remove the plasma, white blood cells, and platelets. The red cells are resuspended in a crystalloid solution. If the hematocrit of the resuspended red blood cells is sufficient, it is transfused to the patient intravenously. The benefits of CS in major spine surgery, bilateral knee replacement, and revision hip surgery are well established (Goulet et al. 1989, Gee et al. 2011, Canan et al. 2013). However, literature reviewing the use of cell saver in orthopedic trauma surgery, specifically acetabular surgery is limited. Our institute performed a retrospective review of 63 consecutive operative acetabular fractures at a level one trauma center. Our study revealed that patients with blood loss of less than 400 mL were 13 times less likely to receive autologous blood, and patients with hemoglobin less than 10.5 were 5 times less likely to receive autologous transfusion (p < 0.05). We also found that no patients with a hemoglobin level less than 10.5 and EBL less than 400 mL received autologous blood return. Autologous blood transfusion had no effect on volume or rate of allogenic blood transfusion. We believed that if a patient's preoperative hemoglobin is less than 10.5 or expected blood loss is less than 400 mL, then CS should have a very limited role, if any, in the preoperative blood conservation strategy. We found ASA greater than 2, BMI greater than 24 and associated fracture type to be a risk factor for high blood loss.
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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