癌症的RNA修饰:功能、机制和治疗意义

IF 4.7 2区 医学 Q1 ONCOLOGY Annual Review of Cancer Biology-Series Pub Date : 2020-03-09 DOI:10.1146/annurev-cancerbio-030419-033357
Huilin Huang, Hengyou Weng, Xiaolan Deng, Jianjun Chen
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引用次数: 54

摘要

在蛋白质编码和非编码rna中发现了170多种化学修饰,并显示出对基因表达的广泛影响。由RNA修饰子的异常表达或突变引起的RNA修饰失调会异常地重编程表转录组并扭曲全局基因表达,从而导致肿瘤发生和耐药性。在这里,我们回顾了目前对人类癌症中异常RNA修饰的功能和潜在机制的了解,特别是几种常见的RNA修饰,包括n6 -甲基腺苷(m6A)、A-to-I编辑、假尿嘧啶(ψ)、5-甲基胞嘧啶(m5C)、5-羟甲基胞嘧啶(hm5C)、n1 -甲基腺苷(m1A)和n4 -乙酰胞苷(ac4C),为靶向RNA修饰的治疗意义和癌症治疗的相关机制提供了见解。
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RNA Modifications in Cancer: Functions, Mechanisms, and Therapeutic Implications
Over 170 chemical modifications have been identified in protein-coding and noncoding RNAs and shown to exhibit broad impacts on gene expression. Dysregulation of RNA modifications caused by aberrant expression of or mutations in RNA modifiers aberrantly reprograms the epitranscriptome and skews global gene expression, which in turn leads to tumorigenesis and drug resistance. Here we review current knowledge of the functions and underlying mechanisms of aberrant RNA modifications in human cancers, particularly several common RNA modifications, including N6-methyladenosine (m6A), A-to-I editing, pseudouridine (ψ), 5-methylcytosine (m5C), 5-hydroxymethylcytosine (hm5C), N1-methyladenosine (m1A), and N4-acetylcytidine (ac4C), providing insights into therapeutic implications of targeting RNA modifications and the associated machineries for cancer therapy.
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来源期刊
CiteScore
14.50
自引率
1.30%
发文量
13
期刊介绍: The Annual Review of Cancer Biology offers comprehensive reviews on various topics within cancer research, covering pivotal and emerging areas in the field. As our understanding of cancer's fundamental mechanisms deepens and more findings transition into targeted clinical treatments, the journal is structured around three main themes: Cancer Cell Biology, Tumorigenesis and Cancer Progression, and Translational Cancer Science. The current volume of this journal has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, ensuring all articles are published under a CC BY license.
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