儿童泌尿系结石的心功能和亚临床心血管风险评估:一项初步研究

IF 0.1 Q4 UROLOGY & NEPHROLOGY Journal of Urological Surgery Pub Date : 2023-06-05 DOI:10.4274/jus.galenos.2022.2022.0043
A. Elmacı, H. Alp, M. Dönmez
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引用次数: 0

摘要

目的:与儿童尿路结石相关的心血管问题的信息有限。本研究的目的是使用超声心动图测量来评估尿石症儿童的心室功能和亚临床心血管风险。材料和方法:前瞻性地将诊断为尿石症的儿童纳入研究,并通过尿液超声检查确认无尿石疾病的儿童。记录了体重指数和血压,以及基本的血清参数。除了脉冲和组织多普勒成像外,还通过经胸超声心动图测量颈动脉内膜-中膜厚度(cIMT)、心外膜脂肪组织(EFT)厚度和皮质周围脂肪组织(PFT)厚度。计算心肌功能指标并进行相关分析。结果:本研究共纳入17名患者(10名男孩),平均年龄8.57±2.62岁。对照组有17名儿童(12名男孩),平均年龄为9.53±1.72岁。在人口统计学和实验室变量方面,两组之间没有统计学上的显著差异。组织多普勒超声心动图显示,研究组左心室、右心室和隔膜的Tei指数显著高于对照组(p均<0.001)。研究组的cIMT(0.041±0.012 vs.0.025±0.002)、EFT(0.432±0.083 vs.0.325±0.032)和PFT厚度(0.138±0.029 vs.0.113±0.008)在统计学上高于对照组(分别为p<0.001、p<0.001和p=0.002),表明CVD风险更高。结论:儿童尿石症早期不仅存在双心室收缩和舒张功能障碍,而且存在亚临床动脉粥样硬化。在儿童尿石症的随访和治疗中应考虑心血管并发症。
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Assessment of Cardiac Functions and Subclinical Cardiovascular Risk in Children with Urolithiasis: A Pilot Study
Objective: Information on cardiovascular problems related to childhood urinary stone disease is limited. The aim of this study was to assess the ventricular functions and subclinical cardiovascular risk in children with urolithiasis using echocardiographic measurements. Materials and Methods: Children diagnosed with urolithiasis were prospectively enrolled in the study as well as children with no urinary stone disease were confirmed via urinary ultrasonography. Body mass index and blood pressures were noted, as well as basic serum parameters. Carotid intima media thickness (cIMT), epicardial fat tissue (EFT) thickness and periaortic fat tissue (PFT) thickness were measured via transthoracic echocardiography in addition to pulsed and tissue Doppler imaging. Myocardial performance indexes were also calculated and correlation analyses were conducted. Results: A total of 17 patients (10 boys) with a mean age of 8.57±2.62 years were included in this study. There were 17 children (12 boys) in the control group and their mean age was 9.53±1.72 years. There was no statistically significant difference between the two groups in terms of demographic and laboratory variables. Tissue Doppler echocardiography revealed that Tei indexes of the left ventricle, right ventricle and septum were significantly higher in the study group than in the controls (p<0.001 for all). The cIMT (0.041±0.012 vs. 0.025±0.002), EFT (0.432±0.083 vs. 0.325±0.032) and PFT thicknesses (0.138±0.029 vs. 0.113±0.008) of the study group was statistically higher than the control group (p<0.001, p<0.001 and p=0.002, respectively) indicating a higher CVD risk. Conclusion: Children with urolithiasis had not only biventricular early systolic and diastolic dysfunction but also subclinical atherosclerosis at early ages. Cardiovascular complications should be considered in the follow-up and treatment of children with urolithiasis.
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来源期刊
Journal of Urological Surgery
Journal of Urological Surgery UROLOGY & NEPHROLOGY-
自引率
33.30%
发文量
42
审稿时长
16 weeks
期刊最新文献
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