Effect of laparoscopic hepatectomy on immune function, inflammatory factors and prognosis of patients with hepatocellular carcinoma

Objective To study the effect of laparoscopic hepatectomy resection on immune function, inflammatory factors and prognosis of patients. Methods One hundred and four patients with hepatocellular carcinoma admitted Zigong Fourth People′s Hospital from July 2015 to December 2016 were selected as the study subjects.According to the different surgical methods, they were randomly divided into observation group and control group with 52 cases in each group.The control group received open hepatectomy, while the observation group received laparoscopic hepatectomy.The immune function, inflammatory factors, and surgery related indicators were compared between the two groups. Results The observation time of the observation group was significantly longer than that in the control group.The blood loss was significantly less than the control group.Gastrointestinal function recovery time and postoperative hospital stay were significantly shorter than control group (t=7.553, 13.855, 15.100, 16.873, all P<0.01), three days after surgery, the serum IgA, IgG, and IgM levels were significantly higher than control group (t=16.009, 10.076, 14.138, all P<0.01). The levels of IL-6, IL-10 and TNF-α were significantly lower than the control group (t=8.538, 6.851, 11.103, P<0.05, all P<0.01). Conclusion Laparoscopic hepatectomy can promote the recovery of patients after surgery, which may be related to the reduction of immune function inhibition, inflammatory response and other factors. Key words: Liver cancer; Surgical resection; Laparoscopy; Immune function; Inflammatory factors