大肠癌癌症发病率和死亡率：宾夕法尼亚癌症登记处三十年来的趋势

IF 2.7 Q3 ONCOLOGY Colorectal Cancer Pub Date : 2023-07-25 DOI:10.2217/crc-2022-0011

Jonathan T Pham, W. Wong, Vonn Walter, J. Scow, M. Deutsch, A. Kulaylat

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摘要

目的：本研究旨在通过国家范围的登记，以种族、年龄和农村为重点，研究癌症（CRC）的发病率和死亡率趋势。方法：从1990年到2019年，通过宾夕法尼亚州癌症登记处使用Joinpoint回归对CRC年龄调整后的发病率和死亡率进行检查，以建立平均年百分比变化（AAPC）模型。结果：在宾夕法尼亚州，无论种族或癌症分期如何，发病率（AAPC-1.7）和死亡率（AAPC-2.5）都有所下降，21世纪初的变化表明下降率更高。相反，50岁以下的患者CRC发病率上升（AAPC 1.8）。农村县的死亡率高于城市县。结论：在宾夕法尼亚州，除了50岁以下的患者外，CRC的发病率和死亡率在过去三十年中都有所下降。

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Colorectal cancer incidence and mortality: trends from the Pennsylvania Cancer Registry across three decades

Aim: This study aims to examine trends in incidence and mortality of colorectal cancer (CRC) using a state-wide registry, focusing on race, age, and rurality. Methods: From 1990 to 2019, CRC age-adjusted incidence and mortality were examined through the Pennsylvania Cancer Registry using Joinpoint Regression to model average annual percent changes (AAPC). Results: In Pennsylvania, there was a decline in incidence (AAPC -1.7) and mortality (AAPC -2.5), consistent regardless of race or cancer stage, with an inflection in the 2000s demonstrating greater rate of decrease. Conversely, patients under 50 saw rising CRC incidence (AAPC 1.8). Rural counties showed higher mortality than urban counties. Conclusion: Across Pennsylvania, the incidence and mortality rates of CRC have decreased over the past three decades, apart from patients under 50.

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Colorectal Cancer ONCOLOGY-

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期刊介绍： Colorectal cancer is a major cause of morbidity and mortality, particularly in the developed world. Risk factors for colorectal cancer are on the rise in many countries; populations are aging, and obesity and diabetes are increasing. National screening programs are helping to detect cancer while it is still curable; however, colorectal cancer remains the third leading cause of cancer deaths in the USA and options are still limited for those with more advanced disease. Consequently, colorectal cancer is a major research priority for government, pharmaceutical companies and non-profit organizations. Research into diagnosis and optimum treatment of the disease is progressing rapidly, with new advances reported every day. Colorectal Cancer presents reviews, analysis and commentary. on all aspects of colorectal cancer.