妊娠期兰索拉唑对胎盘的影响

A. Monfared, M. Shamsi
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引用次数: 0

摘要

兰索拉唑是一种质子泵抑制剂,广泛应用于胃-十二指肠溃疡和疾病的治疗。然而,没有足够的数据表明兰索拉唑对胎盘屏障完整性的不良影响。因此,本研究旨在确定兰索拉唑是否会影响胎盘结构。材料与方法:选取24只Balb/C妊娠小鼠,随机分为1个对照组和3个试验组(n=6)。实验动物在妊娠第6 ~ 16天分别腹腔注射兰索拉唑25、50、100 mg/kg。在妊娠结束和妊娠第17天处死所有动物。取胎盘标本进行组织学检查。组织切片用苏木精-伊红染色,光镜下观察。结果:兰索拉唑治疗后胎盘组织学检查显示细胞有明显改变。与对照组相比,给药小鼠胎盘海绵层的大小明显减小。同时,100 mg/kg兰索拉唑组小鼠胎盘实质出现多态和单核细胞浸润。此外,实验组胎盘组织绒毛间隙扩张,大量血管充血,巨细胞群增加,成纤维细胞增生。结论:本研究的结果为探讨兰索拉唑对小鼠胎盘的影响提供了依据。同时服用,这种药物不应该在怀孕期间开处方。
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The effect of lansoprazole administration during pregnancy on the placenta
Introduction: Lansoprazole is one of the proton pump inhibitor drugs widely used in the treatment of gastro-duodenal ulcers and disorders. However, there is not enough data about unexplored adverse effects of lansoprazole on the integrity of the placental barrier. Therefore, the present study was conducted to determine whether placental structure could be affected by lansoprazole administration. Materials and methods: A total of 24 pregnant Balb/C mice were randomly divided into one control and three experiment groups (n=6).The experimental animals were given 25, 50 and 100 mg/kg of lansoprazole intraperitoneally on days 6-16 of pregnancy. At the end point and on the day 17 of gestation all animals were sacrificed. Then, the placentas specimens were taken and processed for histological examinations. Histological sections were stained with hematoxylin-eosin and were examined under light microscopy. Results: The histological examinations showed remarkable cellular changes in the placenta after treatment with lansoprazole. The placentas from drug administrated mice exhibited conspicuous decrease in the spongy layers size when compared with controls. Also, both polymorph and mononuclear cell infiltration into placental parenchyma were seen in the animals treated with 100 mg/kg lansoprazole. In addition, dilation of the intervillous space, massive vasculature congestion, increased giant cell population and fibroblastic proliferation were seen in the placental tissues from experimental groups. Conclusion: The findings of the present study led us to investigate the effect of the lansoprazole administration on the mouse placenta. Taken together, this drug should not be prescribed during pregnancy.
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