{"title":"新的1,3,4-恶二唑基希夫碱衍生物:合成、表征和抗菌活性与硅研究","authors":"J. Lalpara, S. Hadiyal, J. Dhalani, G. Dubal","doi":"10.17628/ECB.2021.10.139-146","DOIUrl":null,"url":null,"abstract":"A series of novel 1,3,4-oxadiazole based Schiff base derivatives were designed and synthesized using the efficient strategy with excellent yields. Synthesized molecules evaluated in vitro antibacterial studies in contradiction of microorganisms, namely Escherichia coli , Klebsiella pneumoniae, Bacillus subtilis , and Bacillus megaterium . The bioassay result revealed that most of tested compounds good to moderate inhibition against microorganisms. Some among them show excellent inhibitory effects towards the Gram-positive and Gram-negative bacteria. Besides, the drug-likeness, lipophilicity and cytotoxicity.","PeriodicalId":11880,"journal":{"name":"European Chemical Bulletin","volume":"10 1","pages":"139-146"},"PeriodicalIF":0.0000,"publicationDate":"2021-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"NEW 1,3,4-OXADIAZOLE BASED SCHIFF BASE DERIVATIVES: SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY ALONG WITH IN SILICO STUDIES\",\"authors\":\"J. Lalpara, S. Hadiyal, J. Dhalani, G. Dubal\",\"doi\":\"10.17628/ECB.2021.10.139-146\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A series of novel 1,3,4-oxadiazole based Schiff base derivatives were designed and synthesized using the efficient strategy with excellent yields. Synthesized molecules evaluated in vitro antibacterial studies in contradiction of microorganisms, namely Escherichia coli , Klebsiella pneumoniae, Bacillus subtilis , and Bacillus megaterium . The bioassay result revealed that most of tested compounds good to moderate inhibition against microorganisms. Some among them show excellent inhibitory effects towards the Gram-positive and Gram-negative bacteria. Besides, the drug-likeness, lipophilicity and cytotoxicity.\",\"PeriodicalId\":11880,\"journal\":{\"name\":\"European Chemical Bulletin\",\"volume\":\"10 1\",\"pages\":\"139-146\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-01-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Chemical Bulletin\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.17628/ECB.2021.10.139-146\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Chemistry\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Chemical Bulletin","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17628/ECB.2021.10.139-146","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Chemistry","Score":null,"Total":0}
NEW 1,3,4-OXADIAZOLE BASED SCHIFF BASE DERIVATIVES: SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY ALONG WITH IN SILICO STUDIES
A series of novel 1,3,4-oxadiazole based Schiff base derivatives were designed and synthesized using the efficient strategy with excellent yields. Synthesized molecules evaluated in vitro antibacterial studies in contradiction of microorganisms, namely Escherichia coli , Klebsiella pneumoniae, Bacillus subtilis , and Bacillus megaterium . The bioassay result revealed that most of tested compounds good to moderate inhibition against microorganisms. Some among them show excellent inhibitory effects towards the Gram-positive and Gram-negative bacteria. Besides, the drug-likeness, lipophilicity and cytotoxicity.
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