姜黄和姜黄素对CCI模型大鼠神经性疼痛行为反应的影响

Q3 Medicine Journal of Medicinal Plants Pub Date : 2020-09-01 DOI:10.29252/jmp.19.75.141

H. Safakhah, A. Rashidy-Pour, F. Mohammadzadeh, Abbas Ali Vafaei

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引用次数: 0

摘要

缩写：CCI，慢性缩窄性损伤；脱氧核糖核酸；TNF-α、肿瘤坏死因子α；NO，一氧化氮；烟酰胺腺嘌呤二核苷酸氢；LDH、乳酸脱氢酶；背景：神经炎是引起神经性疼痛的原因之一。事实证明，姜黄和姜黄素具有抗神经炎的作用，可以减轻神经性疼痛。目的：研究姜黄和姜黄素对大鼠慢性收缩性损伤（CCI）行为反应的影响。方法：本实验采用Wistar雄性大鼠（200-250gr）。对于CCI的创建，采用了Bennet和Xie（1988）的方法。神经炎发生2周后，开始注射姜黄60mg/kg和姜黄素30和60mg/kg，并持续到第26天

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The effect of turmeric and curcumin on neuropathic pain behavioral response of CCI model in rats

Abbreviations: CCI, Chronic Constriction Injury; DNA, Deoxyribonucleic Acid; TNF-α, Tumor necrosis factor alpha; NO, Nitric Oxide; NADH, Nicotinamide Adenine Dinucleotide Hydrogen; LDH, Lactate dehydrogenase; Background: Neuritis is one of the causes of neuropathic pains. It is proved that turmeric and curcumin have anti-neuritis effect that may be reduce of neuropathic pain. Objective: In this study, effects of turmeric and curcumin have been evaluated on behavioral response resulted from chronic constriction injury (CCI) in rat. Methods: In this experimental study Wistar male rat (200-250 gr) were used. For create of CCI, Bennet and Xie (1988) method has been used. 2 weeks after neuritis occurrence, turmeric 60 mg/kg and curcumin 30 and 60 mg/kg injection have been begun and continued until 26 th day as

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来源期刊

Journal of Medicinal Plants Medicine-Complementary and Alternative Medicine

CiteScore

1.60

自引率

0.00%

发文量

期刊介绍： The Journal of Medicinal Plants is published quarterly. This journal contains articles in the fields of basic and clinical sciences related to medicinal plants including pharmacognosy, basic and clinical pharmacology, basic and clinical toxicology, and pharmacology.