Single Versus Multiple Doses of Surfactant Treatment in Preterm Infants

Ad dress for Cor res pon den ce Betül Siyah Bilgin, Ege University Faculty of Medicine, Department of Pediatrics, Division of Neonatology, İzmir, Turkey Phone: +90 232 390 12 82 E-mail: betulsiyah@yahoo.com ORCID: orcid.org/0000-0003-3807-4809 Re cei ved: 08.11.2018 Ac cep ted: 19.04.2019 Introduction In 1959, Avery et al. (1) showed that a deficiency of surface-active material (surfactant) may be significant in the pathogenesis of hyaline membrane disease in preterm infants. Exogenous surfactant was first used in Respiratory Distress syndrome (RDS) treatment by Fujiwara et al. (2) in 1980. Exogenous Surfactant increases the lung compliance and functional residual capacity at expiration, provides homogenous gas distribution at inspiration and increases oxygenation and survival in RDS patients (3).