Agnimantha不同植物部位的抗炎特征:阿育吠陀文献中列举的两个实体的比较评价

N. Brindavanam, G. Kimothi, P. Reddanna, Rajaram Azad
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引用次数: 0

摘要

背景:Agnimantha是bṛhatpañcamūla(5种树种的根药)的组成部分,而bṛhatpañcamūla又是阿育吠陀药物实践中使用的daśamūla的一部分。传统上,bṛhatpañcamūla的概念设想了这些树种的根/根树皮的使用。总的来说,茎树皮的使用在几十年前开始流行于daśamūla这个子组。根据阿育吠陀药用植物词典的描述,有两个物种被认为是Agnimantha viz. Clerodendrum phlomidis L.f。;;;;;;;:唇形科)。目的:为了解决与根或茎树皮使用相关的可持续性问题,在bṛhatpañcamūla组上进行了一项全面的研究。该研究将候选提取物的抗炎特性置于中心位置。作为本研究的一部分,还对两种被用作Agnimantha的物种进行了比较评估。研究方法:采用在印度不同地区采集的黄菖蒲(C. phlomidis)和整合叶(P. integrifolia)的不同植物部位(根皮、茎皮、叶和幼根)。每个样品依次提取到四种溶剂中。这些提取物通过一系列体外实验来评估其抗炎特性,包括抑制5-脂氧合酶(5-LOX)、环氧合酶1和2 (COX-1和COX-2)等调节酶,以及分析lps刺激的RAW 264.7细胞中促炎和抗炎细胞因子的表达。结果与结论:两种植物均表现出不同程度的抗炎活性。然而,12个月大的整合叶根茎样本被发现对所有炎症标志物具有深远的影响。在抗炎方面,该样本被36个月大的黑根所跟踪。基于这些观察,该研究建议使用12个月的P. integrifolia根(通常称为Bṛhat-agnimantha)作为daśamūla的一部分。由于采收周期为12个月,因此可以使用高密度短期种植方案生产根,以解决与使用根或茎皮相关的可持续性问题。
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Anti-inflammatory profile of different plant parts of Agnimantha: A comparative evaluation of two entities enumerated in ayurvedic literature
Background: Agnimantha is a constituent of the bṛhatpañcamūla (the roots drugs of 5 tree species) which in turn is a part of daśamūla used in Ayurvedic pharmaceutical practices. Traditionally, the concept of bṛhatpañcamūla envisages the usage of root/ root bark of these tree species. By and large, use of stem bark came into vogue many decades ago for this sub-group of daśamūla. Going by descriptions in Ayurvedic lexicon of medicinal plants- two species are considered as Agnimantha viz. Clerodendrum phlomidis L.f. (Fam.: Lamiaceae) and Premna integrifolia L. (Syn. Premna serratifolia L) (Fam.: Lamiaceae). Objective: With an objective to address sustainability concerns associated with use of root or stem bark a comprehensive study was carried out on bṛhatpañcamūla group. This study kept the anti-inflammatory profile of candidate extracts in the centre-stage. As a part of this study, comparative assessment of two species used as Agnimantha was also carried out. Study Methodology: Different plant parts (Root bark, Stem bark, Leaves and Young roots) of C. phlomidis and P. integrifolia were collected from different parts of India. Each sample was extracted successively into four solvents. These extracts were evaluated for their anti-inflammatory profile using a battery of in-vitro assays, involving inhibition of regulatory enzymes like 5-lipoxygenase (5-LOX), cyclooxygenase 1&2 (COX-1 & COX-2) and analysis of the expression of pro- and anti-inflammatory cytokines in LPS-stimulated RAW 264.7 cells.Result and Conclusions: Both the species were observed to exhibit anti-inflammatory activity of varied degrees in this study. However, the sample of 12 months old roots of P. integrifolia was found to possess profound effect on all markers of inflammation. This sample was followed by 36 months old roots of C. phlomidis in terms of anti-inflammatory profile. Basing on these observations, the study suggests the use of 12 months roots of P. integrifolia (often referred to as Bṛhat-agnimantha) as part of daśamūla. Since the harvesting cycle is of 12 months, it is possible to produce the roots using High-Density Short-Term plantation protocols to address the sustainability concerns associated with use of root or stem bark.
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