G. Ramnath, Shathya Jayaraman, R. Thirugnanasampandan, Bhuvaneswari Gunasekaran, Akila Gopalakrishnan
{"title":"锦鲤化学成分分析、抗氧化、抗乙酰胆碱酯酶及细胞毒性评价春天的水果油","authors":"G. Ramnath, Shathya Jayaraman, R. Thirugnanasampandan, Bhuvaneswari Gunasekaran, Akila Gopalakrishnan","doi":"10.55251/jmbfs.6135","DOIUrl":null,"url":null,"abstract":"Plant derived essential oils are easily available source for healthcare purpose and it creates increased attention due to undesirable effects of chemically synthesized drugs. Murraya koenigii (L.) Spreng. raw fruit oil was extracted, and its chemical constituents was analyzed. Antioxidant and acetylcholinesterase inhibitory effect was tested under in vitro. MTT assay for evaluating cytotoxic effect on HeLa cells was done. β-phellandrene was identified as major compound in the extracted fruit oil. Scavenging of DPPH radical, inhibition of lipid peroxidation and protection of deoxyribose were found to be excellent. A dose dependent antiacetylcholinesterase activity of oil was observed with IC50 value as 448.12±0.02µg/mL. A significant growth inhibitory effect of oil on cervical cancer cells (HeLa) was measured with an IC50 value of 194.1±0.03µg/mL. Overall, the essential oil extracted from raw fruit of Murraya koenigii (L.) Spreng exhibited several biological properties, and it could be considered for plant-based medicine preparations.","PeriodicalId":16348,"journal":{"name":"Journal of microbiology, biotechnology and food sciences","volume":" ","pages":""},"PeriodicalIF":0.6000,"publicationDate":"2023-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"CHEMICAL COMPOSITION ANALYSIS AND EVALUATION OF ANTIOXIDANT, ANTIACETYLCHOLINESTERASE AND CYTOTOXICITY OF MURRAYA KOENIGII (L.) SPRENG FRUIT OIL\",\"authors\":\"G. Ramnath, Shathya Jayaraman, R. Thirugnanasampandan, Bhuvaneswari Gunasekaran, Akila Gopalakrishnan\",\"doi\":\"10.55251/jmbfs.6135\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Plant derived essential oils are easily available source for healthcare purpose and it creates increased attention due to undesirable effects of chemically synthesized drugs. Murraya koenigii (L.) Spreng. raw fruit oil was extracted, and its chemical constituents was analyzed. Antioxidant and acetylcholinesterase inhibitory effect was tested under in vitro. MTT assay for evaluating cytotoxic effect on HeLa cells was done. β-phellandrene was identified as major compound in the extracted fruit oil. Scavenging of DPPH radical, inhibition of lipid peroxidation and protection of deoxyribose were found to be excellent. A dose dependent antiacetylcholinesterase activity of oil was observed with IC50 value as 448.12±0.02µg/mL. A significant growth inhibitory effect of oil on cervical cancer cells (HeLa) was measured with an IC50 value of 194.1±0.03µg/mL. Overall, the essential oil extracted from raw fruit of Murraya koenigii (L.) Spreng exhibited several biological properties, and it could be considered for plant-based medicine preparations.\",\"PeriodicalId\":16348,\"journal\":{\"name\":\"Journal of microbiology, biotechnology and food sciences\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2023-08-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of microbiology, biotechnology and food sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.55251/jmbfs.6135\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"FOOD SCIENCE & TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of microbiology, biotechnology and food sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.55251/jmbfs.6135","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
CHEMICAL COMPOSITION ANALYSIS AND EVALUATION OF ANTIOXIDANT, ANTIACETYLCHOLINESTERASE AND CYTOTOXICITY OF MURRAYA KOENIGII (L.) SPRENG FRUIT OIL
Plant derived essential oils are easily available source for healthcare purpose and it creates increased attention due to undesirable effects of chemically synthesized drugs. Murraya koenigii (L.) Spreng. raw fruit oil was extracted, and its chemical constituents was analyzed. Antioxidant and acetylcholinesterase inhibitory effect was tested under in vitro. MTT assay for evaluating cytotoxic effect on HeLa cells was done. β-phellandrene was identified as major compound in the extracted fruit oil. Scavenging of DPPH radical, inhibition of lipid peroxidation and protection of deoxyribose were found to be excellent. A dose dependent antiacetylcholinesterase activity of oil was observed with IC50 value as 448.12±0.02µg/mL. A significant growth inhibitory effect of oil on cervical cancer cells (HeLa) was measured with an IC50 value of 194.1±0.03µg/mL. Overall, the essential oil extracted from raw fruit of Murraya koenigii (L.) Spreng exhibited several biological properties, and it could be considered for plant-based medicine preparations.
期刊介绍：
The Journal of Microbiology, Biotechnology and Food Sciences is an Open Access, peer-reviewed online scientific journal published by the Faculty of Biotechnology and Food Sciences (Slovak University of Agriculture in Nitra). The major focus of the journal is regular publishing of original scientific articles, short communications and reviews about animal, plant and environmental microbiology (including bacteria, fungi, yeasts, algae, protozoa and viruses), microbial, animal and plant biotechnology and physiology, microbial, plant and animal genetics, molecular biology, agriculture and food chemistry and biochemistry, food control, evaluation and processing in food science and environmental sciences.
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