含有抗氧化基团的塔克林衍生物

IF 0.8 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY Doklady Chemistry Pub Date : 2023-02-15 DOI:10.1134/S0012500822700094

I. V. Serkov, A. N. Proshin, N. V. Kovaleva, N. P. Boltneva, E. V. Rudakova, G. F. Makhaeva, S. O. Bachurin

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引用次数: 0

摘要

利用不同烷基链长度的烷基亚胺或烷基胺连接剂(C2-C4)，开发了一种以他林分子与香兰素片段偶联为基础合成多目标化合物的方法。合成的共轭物能有效抑制胆碱酯酶，取代乙酰胆碱酯酶外周阴离子位点上的丙酸，具有潜在的抗聚集性，并具有较高的抗氧化活性。

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Tacrine Derivatives Containing an Antioxidant Moiety

An approach was developed for the synthesis of multitarget compounds based on a tacrine molecule conjugated with a vanillin moiety using alkylimine or alkylamine linkers with different alkyl chain lengths (C2–C4). The synthesized conjugates effectively inhibit cholinesterases, displace propidium from the peripheral anionic site of acetylcholinesterase, which implies potential antiaggregant properties, and exhibit high antioxidant activity.

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来源期刊

Doklady Chemistry 化学-化学综合

CiteScore

1.20

自引率

12.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Doklady Chemistry is a journal that publishes new research in chemistry and chemical engineering of great significance. Initially the journal was a forum of the Russian Academy of Science and published only best contributions from Russia in the form of short articles. Now the journal welcomes submissions from any country in the English or Russian language. Every manuscript must be recommended by Russian or foreign members of the Russian Academy of Sciences.