干眼综合征治疗各种类型屈光不正的可能性

M. Kovalevskaya, V. B. Antonyan, M. I. Sergeeva
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引用次数: 0

摘要

目的:评价Optinol治疗对不同类型屈光不正医学生眼表状态的影响。材料和方法。该研究涉及3组患者:两组临床组和一组对照组。第一临床组为34名轻度、中度或高度远视学生(68眼),平均年龄20.1±0.5岁。第二临床组包括47名轻度、中度或高度近视学生(94眼),平均年龄20.6±0.9岁。对照组由60名学生(120眼)组成,平均年龄21.4±1.2岁,无眼科疾病。每组连续接受三种不同配方的Optinol:Optinol®温和修复:右旋泛醇2%和透明质酸钠0.15%,Optinol™深层补水:透明质酸盐0.4%,Optinol®快速保湿剂:透明质钠0.21%。采用问卷调查的方法,揭示患者的病史和典型的主诉。通过生物显微镜评估眼睑和结膜的状态。为了诊断干眼综合征(DES),使用了特殊的测试:LIPKOF、Schirmer和Norn测试。后果尽管第一组(远视)的LIPKOF评分较高,显示为III期,而第二组(近视)的评分为I期,但第二组的Norn测试评分下降幅度更大。远视组的LIPKOF测试有所改善,降至1.23±0.10mm(I期),相当于一个结膜褶皱。泪膜稳定性指数(Norn检验)在第1组增加3.1±0.1秒,在第2组增加2.2±0.2秒。结论:DES在远视学生中更常见。Optinol是一种以病因为导向的药物,靶向泪液生成障碍和眼表变化。该药物具有较高的疗效、良好的耐受性和安全性,因此可推荐用于治疗多种类型的屈光不正。
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Possibilities of dry eye syndrome therapy in various types of ametropia
Purpose: to evaluate the impact of Optinol treatment on the ocular surface state in medical students with various types of ametropia.Material and methods. The study involved 3 groups of patients: two clinical groups and a control group. The first clinical group consisted of 34 students (68 eyes) with mild, moderate or high hyperopia, averagely aged 20.1 ± 0.5 years. The second clinical group consisted of 47 students (94 eyes) with mild, moderate or high myopia, average aged 20.6 ± 0.9 years. The control group was composed of 60 students (120 eyes), averagely aged 21.4 ± 1.2 years, with no ophthalmic pathologies. Each group received Optinol consecutively in three different formulations: Optinol® Gentle Repair: dexpanthenol 2 % and sodium hyaluronate 0.15 %, Optinol® Deep Hydration: sodium hyaluronate 0.4 %, Optinol® Express Moisturizer: sodium hyaluronate 0.21 %. The case histories of the patients and typical complaints were revealed by the questionnaire method. The state of the eyelids and the conjunctiva was assessed by biomicroscopy. To diagnose the dry eye syndrome (DES), special tests were used: LIPKOF, Schirmer and Norn tests.Results. Despite the higher LIPKOF scores in the 1st (hyperopic) group, showing stage III as compared to the 2nd (myopic) group where it scored stage I, the Norn test score showed a stronger reduction in the 2nd group. The LIPKOF test improved in the hyperopic group, falling to 1.23 ± 0.10 mm (stage I), which corresponded to one conjunctival fold. The index of tear film stability (Norn's test) increased in group 1 by 3.1 ± 0.1 sec, and in group 2 by 2.2 ± 0.2 sec.Conclusion. DES was found to be more frequent in hyperopic students. Optinol is a pathogenetically oriented drug, targeting tear production disorders and ocular surface changes. The drug demonstrates high efficacy, good tolerability and safety profile, so that it could be recommended for managing multiple types of ametropia.
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来源期刊
CiteScore
0.50
自引率
0.00%
发文量
107
审稿时长
16 weeks
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