The mechanism of Action and Potential Impact of Flaxseed on Gastrointestinal Manifestations in Cystic Fibrosis: a Narrative Review

Context: Cystic fibrosis (CF) is an inherited disease that leads to death at a young age. No definite treatment has yet been found to CF. Therefore, it is important to find new therapeutic and medicinal approaches for CF. Flaxseed is an antioxidant dietary and anti-inflammatory supplement with a high omega-3 fatty acid content. In this article, the mechanism of action potential of Flaxseed as a novel supplemental treatment for CF is discussed. Evidence Acquisition: In this review, we searched Iranian Traditional Medicine (ITM) that Zakhire-Kharazmshahi and Qanoon fi al-teb are two examples of such sources. Then, from inception to October 2020, data sources including Google Scholar and Pubmed in the English language were comprehensively explored for the mechanism for action potentials of this herbal remedy on CF. Results: Flaxseed may possess effects on CF gastrointestinal disorders due to its properties, including consumer acceptance as a functional food, being the best non-animal reservoir of omega 3 fatty acid, alpha-linolenic acid )ALA(, and soluble fiber, as well as its anti-inflammatory and antibacterial effects with modulating intestinal microbiota. Conclusion: Regarding the mentioned potential mechanisms of action, it could be hypothesized that Flaxseed can serve as a novel medicine for CF.