甲基- cpg结合蛋白2在疱疹后神经痛中的临床意义:一项观察性研究

IF 0.1 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Investigacion clinica Pub Date : 2022-03-23 DOI:10.54817/ic.v63n1a07
Zhijian Wang, W. Shen, Mengye Zhu, Mu Xu, Mizhen Qiu, Daying Zhang, Shibiao Chen
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引用次数: 0

摘要

本研究旨在探讨甲基- cpg结合蛋白2 (MECP2)在带状疱疹后神经痛(PHN)患者中的临床意义。该前瞻性病例对照研究于2017年4月至2019年12月纳入了319例PHN患者。分别采用匹兹堡睡眠质量评分和SF-36量表对患者的睡眠质量和生活质量进行评估。采用酶联免疫吸附法(ELISA)检测血清MECP2、CRP、IL-6、TNF-α水平。采用视觉模拟评分法(visual analogue scale, VAS)评价患者的疼痛状况。与非PHN患者相比,PHN患者MECP2水平显著升高。重度疼痛患者血清MECP2水平最高,轻度疼痛患者最低。同样,MECP2低表达患者发生剧烈疼痛的频率明显低于MECP2高表达患者。此外,PHN患者血清炎症因子CRP、IL-6、TNF-α水平明显升高,且随疼痛程度的加重而升高。PHN患者血清MECP2水平与CRP、IL-6、TNF-α呈正相关。研究前,MECP2水平较低的患者SF-36评分明显高于MECP2水平较高的患者,匹兹堡评分和VAS评分明显低于MECP2水平较高的患者。然而,一个月后,患者之间没有发现显著差异。ROC曲线显示MECP2具有作为PHN诊断生物标志物的潜力。总之,较高的血清MECP2水平与更严重的疼痛状况和炎症因子释放增加有关。
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Clinical significance of methyl-CpG binding protein 2 in postherpetic neuralgia: an observational study
The present study was aimed to investigate the clinical significance of methyl-CpG binding protein 2 (MECP2) in patients with postherpetic neuralgia (PHN). This prospective case control study enrolled 319 cases of PHN patients from April 2017~December 2019. The patients’ sleep quality and quality of life were evaluated using the Pittsburgh sleep quality score and the SF-36 scale, respectively. The serum levels of MECP2, CRP, IL-6 and TNF-α were tested using enzyme linked immunosorbent assay (ELISA). The pain condition of the patients was evaluated using the visual analogue scale (VAS). The levels of MECP2 were significantly increased in PHN patients compared with the patients without PHN. Serum MECP2 levels were the highest in patients with severe pain, and were the lowest in patients with mild pain. Similarly, the frequency of severe pain in patients with low expression of MECP2 was significantly lower than the patients with higher MECP2 expression. Besides, serum levels of inflammatory factors CRP, IL-6 and TNF-α were markedly increased in PHN patients, which were also increased with the increase of the severity of pain. CRP, IL-6 and TNF-α were positively correlated with serum levels of MECP2 in PHN patients. Before the study, patients with lower MECP2 levels showed a significantly higher SF-36 score and lower Pittsburgh and VAS scores than patients with higher levels of MECP2. However, after one month, no significant difference was found between the patients. ROC curve showed MECP2 had the potential as a diagnostic biomarker for PHN. In conclusion, higher serum MECP2 levels are associated with a more severe pain condition and increased release of inflammatory factors.
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来源期刊
Investigacion clinica
Investigacion clinica MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
0.20
自引率
50.00%
发文量
2
审稿时长
>12 weeks
期刊介绍: Estudios humanos, animales y de laboratorio relacionados con la investigación clínica y asuntos conexos.
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