富含蛋氨酸食物营养治疗非酒精性脂肪肝的疗效观察

IF 0.5 4区 医学 Q4 NUTRITION & DIETETICS Archivos Latinoamericanos De Nutricion Pub Date : 2023-08-01 DOI:10.37527/2023.73.2.004
J. Morales-Romero, María Cristina Ortíz León, Héctor Hernández-Gutierrez, Roberto A. Bahena-Cerón, Aidé Miranda-Reza, José A. Marin-Carmona, Edit Rodríguez-Romero, Silvia I. Mora-Herrera, Jonathan Garcia-Roman, J. Pérez-Carreón, E. Rivadeneyra-Domínguez, Gabriel Riande-Juárez, Rebeca Garcia-Roman
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引用次数: 0

摘要

介绍。非酒精性脂肪性肝病(NAFLD)可导致非酒精性脂肪性肝炎(NASH)、肝硬化和肝癌。NAFLD的治疗包括改变热量摄入和体力活动。NAFLD具有促氧化性质;因此,假设抗氧化剂蛋氨酸可以用于治疗这种疾病是合乎逻辑的。的目标。本研究旨在评价高蛋氨酸饮食疗法对NAFLD患者的影响。材料和方法。一项为期三个月的随机临床研究。本研究纳入121例NAFLD患者,年龄≥20岁(实验组56例,对照组65例),均为随机分组,性别匹配,来自墨西哥Xalapa市ISSSTE医院。指导患者摄入食物以满足推荐的每日蛋氨酸剂量,并计算每日摄入量。蛋氨酸效应以NAFLD的回归和生活质量的改善来衡量。结果。营养治疗诱导NAFLD消退,降低中心脂肪堆积、血压和脂肪肝指数。一些参数,如肝酶,没有改变。治疗后患者的生活质量得到改善。结论。在本研究中,我们仅在三个月的饮食中发现了肝保护作用,因此,在我们研究的耐药参数中,更长的饮食可能会产生更多相关的益处。
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Efficacy of nutrition therapy with food rich in methionine for treating nonalcoholic fatty liver
Introduction. Non-Alcoholic Fatty Liver disease (NAFLD) can lead to Non Alcoholic steatohepatitis (NASH), cirrhosis, and liver cancer. The treatment for NAFLD involves modification of caloric intake and physical activity. NAFLD has a pro-oxidant nature; therefore, it is logical to suppose that the antioxidant methionine can be used as a treatment for this disease. Aim. This study aimed to evaluate the effect of high-methionine dietary therapy on patients with NAFLD. Materials and methods. A randomized clinical study was conducted over three months. In this study, 121 NAFLD patients participated, and the age of the participants was ≥ 20 years (experimental group included 56 and control group 65), all of whom were randomized and matched by sex, recluted from the ISSSTE hospital in Xalapa, Mexico. The patients were instructed to consume food to cover the recommended methionine daily doses, and the daily amount consumed was calculated. Methionine effect was measured as NAFLD regression and quality of life improvement. Results. Nutritional therapy induced NAFLD regression and diminished central fat accumulation, blood pressure, and the fatty liver index. Some parameters, such as liver enzymes, did not changed. The quality of life of patients improved after treatment. Conclusions. In this study, we show a hepatoprotective effect induced only in three months of chances in the diet, thus, a longer diet may generate more relevant benefits in the resistant parameters of our study.
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来源期刊
CiteScore
0.50
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0.00%
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31
期刊介绍: Archivos Latinoamericanos de Nutrición (ALAN) is the official publication of the Sociedad Latinoamericana de Nutición (SLAN), for the dissemination of knowledge in the fields of food and nutrition, principally throughout the American Hemisphere. Articles in Spanish, English, Portuguese and French are accepted, both from the Society members and from nonmembers, in the following categories: 1. General articles (critical scientific reviews); 2. Research articles (originals); 3. Papers in applied nutrition (analytical results from intervention programs and discussion of reconmendations of practical application), and 4. Letters to Editor (short comments of general interest or about scientific facts and results previously published in Archives).
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