微小RNA-221/222簇是否预示着心血管疾病的新时代？

IF 0.2 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Cor et vasa Pub Date : 2023-03-01 DOI:10.33678/cor.2022.050

Lutfu Askin, Okan Tanriverdi

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引用次数: 0

摘要

除了调节基因表达外，微小RNA（miR）还调节信使RNA的降解和翻译速率。MiRs在心血管系统中高表达，表明其在血管健康中发挥着重要作用。动脉粥样硬化过程与miR-221和-222有关。MiRs-221/222具有抗狭窄活性。MiR-221/222可能潜在地作为心肌重塑的标志物。miRs-221/222要被识别为潜在的治疗靶点还有很长的路要走。识别、验证和理解基因靶标的功能至关重要。Klíčováslova：Kardiovaskulárnísystém MikroRNA MiR-221/222

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Is the microRNA-221/222 Cluster Ushering in a New Age of Cardiovascular Diseases?

In addition to regulating gene expression, microRNAs (MiRs) regulate messenger RNA degradation and translation rates. MiRs have a high expression in the cardiovascular (CV) system, indicating an important role in vascular health. The atherosclerotic process has been related to miRs-221 and -222. MiRs-221/222 possess anti-stenotic activity. MiR-221/222 may potentially serve as a marker for myocardial remodeling. There is still a long way yet before miRs-221/222 can be recognized as a potential therapeutic target. Identiﬁ cation, validation, and understanding of the function of gene targets are all critical. Klíčová slova: Kardiovaskulární systém MikroRNA MiR-221/222 Působení proti tvorbě stenóz Remodelace

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