Qian Yang, Na Ma, Yangqing He, Xiaojiao Yu, B. Yao
{"title":"磷酸胺接枝纤维素固定化钯纳米粒子用于尿嘧啶芳基化反应","authors":"Qian Yang, Na Ma, Yangqing He, Xiaojiao Yu, B. Yao","doi":"10.2174/2213337208666210816110719","DOIUrl":null,"url":null,"abstract":"\n\nThe synthesis of 5-arylation uracil nucleosides is an imperative challenge. Especially for the method of suzuki reaction using N-unprotected uracil as materials, which holds potential to enhance the yield. \n\n\n\nIn order to find a more efficient catalyst to increase the yield of aryluracils and aryluridines. \n\n\n\n\nWe first constructed the phosphanamine-grafted cellulose (PAGC) from cellulose material. And then prepared the nanocatalyst PAGC/Pd(0) through heating and reducing the mixture of PAGC and Pa(OAc)2. \n\n\n\nWhen using this nanocatalyst to catalyze the Suzuki reaction of 5-iodouracil or 5-iodouridine and aryl heterocyclic boronic acids. The arylation yields have been a significantly improvement. \n\n\n\nThis means that the resultant nanocatalyst exhibits a remarkable catalytic efficacy for Suzuki arylation of 5-iodouracil and 5-iodouridine.\n","PeriodicalId":10945,"journal":{"name":"Current Organocatalysis","volume":" ","pages":""},"PeriodicalIF":0.9000,"publicationDate":"2021-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Immobilized Palladium nanoparticles on phosphanamine-grafted cellulose for arylation of uracil\",\"authors\":\"Qian Yang, Na Ma, Yangqing He, Xiaojiao Yu, B. Yao\",\"doi\":\"10.2174/2213337208666210816110719\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\\n\\nThe synthesis of 5-arylation uracil nucleosides is an imperative challenge. Especially for the method of suzuki reaction using N-unprotected uracil as materials, which holds potential to enhance the yield. \\n\\n\\n\\nIn order to find a more efficient catalyst to increase the yield of aryluracils and aryluridines. \\n\\n\\n\\n\\nWe first constructed the phosphanamine-grafted cellulose (PAGC) from cellulose material. And then prepared the nanocatalyst PAGC/Pd(0) through heating and reducing the mixture of PAGC and Pa(OAc)2. \\n\\n\\n\\nWhen using this nanocatalyst to catalyze the Suzuki reaction of 5-iodouracil or 5-iodouridine and aryl heterocyclic boronic acids. The arylation yields have been a significantly improvement. \\n\\n\\n\\nThis means that the resultant nanocatalyst exhibits a remarkable catalytic efficacy for Suzuki arylation of 5-iodouracil and 5-iodouridine.\\n\",\"PeriodicalId\":10945,\"journal\":{\"name\":\"Current Organocatalysis\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.9000,\"publicationDate\":\"2021-08-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Organocatalysis\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/2213337208666210816110719\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Organocatalysis","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/2213337208666210816110719","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
Immobilized Palladium nanoparticles on phosphanamine-grafted cellulose for arylation of uracil
The synthesis of 5-arylation uracil nucleosides is an imperative challenge. Especially for the method of suzuki reaction using N-unprotected uracil as materials, which holds potential to enhance the yield.
In order to find a more efficient catalyst to increase the yield of aryluracils and aryluridines.
We first constructed the phosphanamine-grafted cellulose (PAGC) from cellulose material. And then prepared the nanocatalyst PAGC/Pd(0) through heating and reducing the mixture of PAGC and Pa(OAc)2.
When using this nanocatalyst to catalyze the Suzuki reaction of 5-iodouracil or 5-iodouridine and aryl heterocyclic boronic acids. The arylation yields have been a significantly improvement.
This means that the resultant nanocatalyst exhibits a remarkable catalytic efficacy for Suzuki arylation of 5-iodouracil and 5-iodouridine.
期刊介绍：
Current Organocatalysis is an international peer-reviewed journal that publishes significant research in all areas of organocatalysis. The journal covers organo homogeneous/heterogeneous catalysis, innovative mechanistic studies and kinetics of organocatalytic processes focusing on practical, theoretical and computational aspects. It also includes potential applications of organocatalysts in the fields of drug discovery, synthesis of novel molecules, synthetic method development, green chemistry and chemoenzymatic reactions. This journal also accepts papers on methods, reagents, and mechanism of a synthetic process and technology pertaining to chemistry. Moreover, this journal features full-length/mini review articles within organocatalysis and synthetic chemistry. It is the premier source of organocatalysis and synthetic methods related information for chemists, biologists and engineers pursuing research in industry and academia.
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