间充质间质细胞治疗胃肠道疾病的新视角

Q3 Agricultural and Biological Sciences Biological Communications Pub Date : 2022-10-10 DOI:10.21638/spbu03.2022.307
O. Payushina, D. Tsomartova, Yelizaveta Chereshneva, M. Ivanova, N. Pashina, Elina Tsomartova, S. Kuznetsov
{"title":"间充质间质细胞治疗胃肠道疾病的新视角","authors":"O. Payushina, D. Tsomartova, Yelizaveta Chereshneva, M. Ivanova, N. Pashina, Elina Tsomartova, S. Kuznetsov","doi":"10.21638/spbu03.2022.307","DOIUrl":null,"url":null,"abstract":"Mesenchymal stromal cells (MSCs) are a promising resource for cell therapy of different organs and systems, including the gastrointestinal tract (GIT). Therapeutic effect of MSC transplantation in GIT diseases may be partly due to their differentiation into various cellular components of the digestive tube. However, more significant is regulatory influence of MSCs on survival, proliferation, and differentiation of the gastric and intestinal epithelial cells, as well as their immunomodulatory, pro-angiogenic and antifibrotic effects. Data from experiments on animals and clinical trials indicate prospect of using MSCs in various diseases affecting any parts of GIT. However, effective and safe clinical use of MSCs requires an in-depth study of the mechanisms of their therapeutic effect, the development of optimal methods of administration, and risk assessment of adverse effects. This review analyzes MSC participation in regeneration of GIT and systematizes data on the potential of using MSCs in the treatment of gastroenterological diseases.","PeriodicalId":8998,"journal":{"name":"Biological Communications","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"New perspectives on treatment of gastrointestinal diseases: therapeutic potential of mesenchymal stromal cells\",\"authors\":\"O. Payushina, D. Tsomartova, Yelizaveta Chereshneva, M. Ivanova, N. Pashina, Elina Tsomartova, S. Kuznetsov\",\"doi\":\"10.21638/spbu03.2022.307\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Mesenchymal stromal cells (MSCs) are a promising resource for cell therapy of different organs and systems, including the gastrointestinal tract (GIT). Therapeutic effect of MSC transplantation in GIT diseases may be partly due to their differentiation into various cellular components of the digestive tube. However, more significant is regulatory influence of MSCs on survival, proliferation, and differentiation of the gastric and intestinal epithelial cells, as well as their immunomodulatory, pro-angiogenic and antifibrotic effects. Data from experiments on animals and clinical trials indicate prospect of using MSCs in various diseases affecting any parts of GIT. However, effective and safe clinical use of MSCs requires an in-depth study of the mechanisms of their therapeutic effect, the development of optimal methods of administration, and risk assessment of adverse effects. This review analyzes MSC participation in regeneration of GIT and systematizes data on the potential of using MSCs in the treatment of gastroenterological diseases.\",\"PeriodicalId\":8998,\"journal\":{\"name\":\"Biological Communications\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-10-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biological Communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21638/spbu03.2022.307\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Agricultural and Biological Sciences\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biological Communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21638/spbu03.2022.307","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Agricultural and Biological Sciences","Score":null,"Total":0}
引用次数: 0

摘要

间充质基质细胞(Mesenchymal stromal cells, MSCs)是包括胃肠道(GIT)在内的不同器官和系统的细胞治疗的有前途的资源。间充质干细胞移植治疗胃肠道疾病的效果可能部分归因于它们分化为消化道的各种细胞成分。然而,更重要的是MSCs对胃肠上皮细胞的存活、增殖和分化的调节作用,以及其免疫调节、促血管生成和抗纤维化的作用。动物实验和临床试验的数据表明,MSCs有望用于影响GIT任何部位的各种疾病。然而,有效和安全的临床使用间充质干细胞需要深入研究其治疗作用的机制,制定最佳的给药方法,以及不良反应的风险评估。这篇综述分析了间充质干细胞在胃肠道再生中的作用,并对利用间充质干细胞治疗胃肠疾病的潜力进行了系统的数据整理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
New perspectives on treatment of gastrointestinal diseases: therapeutic potential of mesenchymal stromal cells
Mesenchymal stromal cells (MSCs) are a promising resource for cell therapy of different organs and systems, including the gastrointestinal tract (GIT). Therapeutic effect of MSC transplantation in GIT diseases may be partly due to their differentiation into various cellular components of the digestive tube. However, more significant is regulatory influence of MSCs on survival, proliferation, and differentiation of the gastric and intestinal epithelial cells, as well as their immunomodulatory, pro-angiogenic and antifibrotic effects. Data from experiments on animals and clinical trials indicate prospect of using MSCs in various diseases affecting any parts of GIT. However, effective and safe clinical use of MSCs requires an in-depth study of the mechanisms of their therapeutic effect, the development of optimal methods of administration, and risk assessment of adverse effects. This review analyzes MSC participation in regeneration of GIT and systematizes data on the potential of using MSCs in the treatment of gastroenterological diseases.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Biological Communications
Biological Communications Agricultural and Biological Sciences-Agricultural and Biological Sciences (all)
CiteScore
1.70
自引率
0.00%
发文量
21
期刊最新文献
Agreement of bioimpedance analysis and ultrasound scanning for fat mass, fat free mass and body fat percentage evaluation in the group of adult women Natural habitats for the stable existence of wild boars (Sus scrofa) in the North Cancer as a potential sequela of COVID-19 — should we modify 3D cell culture models accordingly? The preparation of samples for studying neutrophils without their isolation Ethanolic extract of Aloe arborescens stimulates neonatal rat calvarial cells proliferation, migration and osteogenic differentiation
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1