The Antidepressant Effects of Domestic Natural Mixed Fragrance Ingredients in Animal Models

Background: This study used inhalation toxicity experiments, open field experiments, and tail suspension tests to investigate the antidepressant effect of a combination of nine types of refined oils extracted from domestic native plants.Methods: Non-irritability was confirmed through an inhalation toxicity test, locomotor activity was measured using an open field test, and the antidepressant effect was assessed by measuring immobility time during a tail suspension test.Results: The inhalation toxicity test confirmed that both samples were non-stimulated with a negative stimulation index of 0.0. In the tail suspension experiment, the floating time was significantly shorter than the depression model, with an average of 142.33±18.31 seconds compared to the control group at 0.5% concentration (F=10.582, p＜.001).Conclusions: This study’s results suggest that combining refined oils extracted from domestic native plants could be used to develop prototypes that effectively alleviate depression. Future studies should include usability evaluation and human application tests to further investigate these potential benefits.