亚硒酸钠通过Akt-mTOR信号通路促进牛乳腺上皮细胞增殖

IF 1.4 4区农林科学 Q3 AGRICULTURE, DAIRY & ANIMAL SCIENCE Journal of Animal and Feed Sciences Pub Date : 2023-04-25 DOI:10.22358/jafs/159458/2023

J. Zhang, Y. Liu, L. Bu, Q. Liu, C. Pei, G. Guo

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引用次数: 0

摘要

本实验旨在评估亚硒酸钠（Na2-SeO3）对牛乳腺上皮细胞（BMEC）增殖的影响，并评估其潜在机制。Na2-SeO3的添加在18至140nM的剂量范围内刺激BMEC增殖。然而，与35nM的Na2Seo3相比，高剂量的Na2Seo 3（＞70nM）没有进一步刺激BMEC增殖。因此，35nM Na2Seo3的添加增加了经历DNA复制的上皮细胞的比例、增殖细胞核抗原（PCNA）的mRNA表达、细胞周期蛋白A2

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Sodium selenite addition promotes the proliferation of bovine mammary epithelial cells through the Akt-mTOR signalling pathway

. The experiment was designed to evaluate the effect of sodium selenite (Na 2 SeO 3 ) on the proliferation of bovine mammary gland epithelial cells (BMECs), and to assess the underlying mechanisms. The addition of Na 2 SeO 3 at doses ranging from 18 to 140 nM stimulated BMEC proliferation. Nevertheless, high doses of Na 2 SeO 3 (> 70 nM) did not further stimulate BMEC proliferation compared to 35 nM Na 2 SeO 3 . Therefore, the addition of 35 nM Na 2 SeO 3 increased the proportion of epithelial cells undergoing DNA replication, mRNA expression of proliferating cell nuclear antigen (PCNA), Cyclin A2

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来源期刊

Journal of Animal and Feed Sciences 农林科学-奶制品与动物科学

CiteScore

2.10

自引率

0.00%

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审稿时长

3 months

期刊介绍： Journal of Animal and Feed Sciences (JAFS, J. Anim. Feed Sci.) has been published by the Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences in Jabłonna (Poland) since 1991. It is a continuation of the Polish-language journal Roczniki Nauk Rolniczych. Seria B, Zootechniczna published by the Polish Academy of Sciences since 1969. JAFS is an international scientific journal published quarterly, about 40 papers per year including original papers, short communications and occasionally reviews. All papers are peer-reviewed and related to basic and applied researches in the field of animal breeding and genetics, physiology of nutrition, animal feeding, feed technology and food preservation. The journal distinguishes the multidisciplinary nature of physiological and nutritional sciences and so includes papers specialized in all fields connected with animal well-being, including molecular and cell biology and the emerging area of genetics.