{"title":"癌症治疗儿童的症状生物标志物：科学现状","authors":"Belinda N Mandrell, Janice S Withycombe","doi":"10.1177/1043454219859233","DOIUrl":null,"url":null,"abstract":"<p><p>The Children's Oncology Group Nursing Discipline has identified the most concerning symptoms during childhood cancer treatment and the need for continued symptom assessment and intervention during treatment trajectory. To develop appropriate interventions, symptom science strategies must explore the biological mechanisms associated with symptoms of cancer and cancer treatment. To explore the associated biological mechanisms, biomarkers have been recommended for inclusion in symptom science studies, when applicable. The biomarker assessed, as well as the method of collection and storage, can affect the reliability and validity of the study results and clinical implication. This review will describe biomarkers that have been described in pediatric oncology symptom science research and provides special considerations for specimen collection and processing.</p>","PeriodicalId":50093,"journal":{"name":"Journal of Pediatric Oncology Nursing","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197220/pdf/","citationCount":"0","resultStr":"{\"title\":\"Symptom Biomarkers for Children Receiving Treatment for Cancer: State of the Science.\",\"authors\":\"Belinda N Mandrell, Janice S Withycombe\",\"doi\":\"10.1177/1043454219859233\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The Children's Oncology Group Nursing Discipline has identified the most concerning symptoms during childhood cancer treatment and the need for continued symptom assessment and intervention during treatment trajectory. To develop appropriate interventions, symptom science strategies must explore the biological mechanisms associated with symptoms of cancer and cancer treatment. To explore the associated biological mechanisms, biomarkers have been recommended for inclusion in symptom science studies, when applicable. The biomarker assessed, as well as the method of collection and storage, can affect the reliability and validity of the study results and clinical implication. This review will describe biomarkers that have been described in pediatric oncology symptom science research and provides special considerations for specimen collection and processing.</p>\",\"PeriodicalId\":50093,\"journal\":{\"name\":\"Journal of Pediatric Oncology Nursing\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2019-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197220/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Pediatric Oncology Nursing\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/1043454219859233\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"NURSING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pediatric Oncology Nursing","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/1043454219859233","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NURSING","Score":null,"Total":0}
Symptom Biomarkers for Children Receiving Treatment for Cancer: State of the Science.
The Children's Oncology Group Nursing Discipline has identified the most concerning symptoms during childhood cancer treatment and the need for continued symptom assessment and intervention during treatment trajectory. To develop appropriate interventions, symptom science strategies must explore the biological mechanisms associated with symptoms of cancer and cancer treatment. To explore the associated biological mechanisms, biomarkers have been recommended for inclusion in symptom science studies, when applicable. The biomarker assessed, as well as the method of collection and storage, can affect the reliability and validity of the study results and clinical implication. This review will describe biomarkers that have been described in pediatric oncology symptom science research and provides special considerations for specimen collection and processing.
期刊介绍：
SPECIAL PATIENTS NEED SPECIAL NURSES
Caring for children with cancer is one of the most technically and emotionally difficult areas in nursing. Not only are you dealing with children and adolescents who hurt, you must reassure and educate families, balance a multitude of other health care professionals, and keep up with ever-changing nursing practice and care. To help special nurses stay aware of the newest effective nursing practices, innovative therapeutic approaches, significant information trends, and most practical research in hematology and pediatric oncology nursing, you need the Journal of Pediatric Oncology Nursing.
The journal offers pediatric hematology, oncology, and immunology nurses in clinical practice and research, pediatric social workers, epidemiologists, clinical psychologists, child life specialists and nursing educators the latest peer-reviewed original research and definitive reviews on the whole spectrum of nursing care of childhood cancers, including leukemias, solid tumors and lymphomas, and hematologic disorders. JOPON covers the entire disease process--diagnosis, treatment, recovery, and survival, as well as end-of-life care.
Six times a year, the Journal of Pediatric Oncology Nursing introduces new and useful nursing care practice and research from around the world that saves you time and effort. Just some of the spirited topics covered include:
Cancer survivorship including later-life effects of childhood cancer, including fertility, cardiac insufficiency, and pulmonary fibrosis
Combination therapies
Hematologic and immunologic topics
Holistic, family-centered supportive care
Improvement of quality of life for children and adolescents with cancer
Management of side effects from surgery, chemotherapy, and radiation
Management of specific symptoms/diseases/co-infections
Medication tolerance differences in children and adolescents
Pain control
Palliative and end of life care issues
Pharmacologic agents for pediatrics/clinical trial results
Psychological support for the patient, siblings, and families
The dynamic articles cover a wide range of specific nursing concerns, including:
Advanced practice issues
Clinical issues
Clinical proficiency
Conducting qualitative and quantitative research
Developing a core curriculum for pediatric hematology/oncology nursing
Encouraging active patient participation
Ethical issues
Evaluating outcomes
Professional development
Stress management and handling your own emotions
Other important features include Guest Editorials from experts in the discipline, Point/Counterpoint debates, Roadmaps (personal insights into the nursing experience), and Proceedings and Abstracts from the annual Association for Pediatric Hematology/Oncology Nurses (APHON) conference.
Your special patients need special nurses--stay special by subscribing to the Journal of Pediatric Oncology Nursing today!
This journal is a member of the Committee on Publication Ethics (COPE).
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