Old and new paradigms in Biochemistry and Molecular Biology

The principles of biochemistry are historically linked to studies on fermentation and the role of enzymes in this process. Thousands of reactions catalyzed by enzymes that are responsible for vital phenomena take place in cells. In later stages it has been shown that these reactions take place in an organized and regulated manner in the intracellular space. Later, biochemical processes such as DNA duplication and gene expression have revealed the role of information in biochemical reactions. The identification of logic modules and circuits through which this information passes is a new stage. Alongside this reductionist approach, recent advances in genomic sequencing, bioinformatics, proteomics, and high-throughput experimentation seek to provide comprehensive knowledge of complex biological systems. Keywords: biochemistry; history; paradigms; systems biology