ETV6-NTRK3基因融合的高级别胶质瘤影像学表现与病理相关性

Juliet Alla, Joshua P Nickerson, MD, Matthew Wood, MD, PhD, M. Mossa-Basha, Christopher G Filippi, D. Zarnow, Jianling Ji, MD, Jaclyn A Biegel, PhD, Yassmine Akkari, PhD, Gisele Ishak, MD, R. Barajas
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引用次数: 0

摘要

对儿童高级别神经胶质瘤的遗传分析显示,在少数高度侵袭性肿瘤中存在ETV6-NTRK3基因融合。这种基因融合的鉴定很重要,因为这些患者可能会从新的靶向治疗中受益。5例ETV6-NTRK3基因融合患者的临床表现、影像学和病理学证实。这一系列病例可能会提高人们对这一实体的认识,并促进基因评估。
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High-grade Glial Tumors Associated with ETV6-NTRK3 Gene Fusion: Imaging Appearance with Pathological Correlate
Genetic analysis of high-grade glial tumors in children has revealed the presence of the ETV6-NTRK3 gene fusion in a small number of highly aggressive‐appearing neoplasms. Identification of this gene fusion is important in that these patients may benefit from new, targeted therapies. Clinical presentation, imaging, and pathologic confirmation were obtained from 5 patients with confirmed ETV6-NTRK3 gene fusion. This case series may raise awareness of this entity and prompt genetic evaluation.
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来源期刊
Neurographics
Neurographics Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
0.20
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0.00%
发文量
12
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