Modular and handheld Raman systems for SERS-based point-of-care diagnostics

This review highlights advancements in recent years concerning surface-enhanced Raman scattering approaches for point-of-care testing applications, with a particular emphasis on spectroscopic interrogation using modular and handheld Raman systems. The surge in interest in remote monitoring research, largely influenced by the coronavirus disease 2019 pandemic, has underscored inconsistencies in the application of the term ‘point-of-care.’ This term is particularly misused when large, centralized lab types of static spectrometers are employed, which contradicts the principle of near-patient testing. We address this contradiction by spotlighting research that employs portable spectrometers, thus pushing the boundaries for future in-field use and emphasizing their potential to enhance point-of-care testing capabilities.