血液灌流治疗内毒素血症的机制及研究现状

Yichen Li, Juanjuan Liu, Hong-xiang Guo
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摘要

内毒素血症是由血液或病变中的细菌释放大量内毒素引起的病理生理学表现。它会导致多器官衰竭、不可逆转的休克,甚至死亡。内毒素血症的死亡率很高。细菌内毒素是引起内毒素血症的主要原因。目前临床上尚无安全有效的治疗内毒素血症的药物。研究表明,血液净化可以有效降低血液中的内毒素水平,从而达到治疗内毒素血症的目的。本文论述了内毒素血症的发病机制、血液灌流治疗技术的发展、不同血液灌流树脂吸附内毒素的机理和研究现状,并对血液灌流吸附材料治疗内毒素血症的性能和安全要求进行了研究,为合成治疗内毒素血症的新型血液灌流吸附材料提供理论支持。关键词:血液灌注;内毒素血症;A吸附机理
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Mechanism and research status of hemoperfusion in endotoxemia treatment
Endotoxemia is a pathophysiological manifestation caused by the release of large amounts of endotoxin from bacteria in the blood or in the lesion. It can cause multiple organ failure, irreversible shock, and even death. The mortality rate of endotoxemiaIt is high. Bacterial endotoxin is the main cause of endotoxemia. At present, there is no safe and effective drug to treat endotoxemia in clinic. Research shows that blood purification can effectively reduce endotoxin level in the blood, then achieve the goal of treatment of endotoxemia. In this paper, the pathogenesis of endotoxemia, the development of hemoperfusion therapy technology, the mechanism and research status of endotoxin adsorption by different hemoperfusion resin were discussed, and the performance and safety requirements of hemoperfusion adsorbent materials for endotoxemia treatment were studied, so as to provide theoretical support for the synthesis of new hemoperfusion adsorption materials for the treatment of endotoxemia. Key words: Hemoperfusion; Endotoxemia; Asorption mechanism
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