氯己定与纳米银漱口水的临床参数评价及龈沟液容量分析

Q3 Biochemistry, Genetics and Molecular Biology Journal of Cellular Biotechnology Pub Date : 2023-08-18 DOI:10.3233/jcb-230116
Shivani Sachdeva, Amit Mani, H. Saluja, R. Kunkulol, Navid Mohammadi, Deepak Abhaya
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引用次数: 0

摘要

背景:口腔生态系统是一个动态格局。除垢和牙根刨平(SRP)是治疗慢性牙周炎的金标准方法,但单独使用它可能无法有效地从难以进入的部位清除牙周病原体。虽然氯己定是对抗口腔微生物最有效的漱口水,但长期使用的副作用表明需要另一种漱口水。因此,本研究旨在了解纳米银漱口水与氯己定漱口水对口腔常见微生物的有效性。目的:评价和比较氯己定(CHX)和纳米银颗粒辅助刮治和根规划(SRP)治疗慢性牙周炎患者的临床和生化结果。方法:从牙周病科招募92例符合纳入和排除标准的广泛性中重度慢性牙周炎患者进行研究。在实验性临床试验中,临床参数也同样如此;评估菌斑指数(PI)、牙龈指数(GI)、探诊深度(PD)、临床附着损失(CAL)。在基线和随访时评估牙龈沟液(GCF)水平的容量分析。使用IBM SPSS Statistics for Windows软件,v. 20.0 (IBM Corp., Armonk, USA)。数据被数字编码并输入到程序中。采用描述性统计和推断性统计比较两组间的反应。结果:采用描述性统计和推断性统计进行统计分析,两组患者PI、GI、PPD、CAL、GCF从基线到随访3个月均有组内显著降低。两组间所有参数的组内差异均有统计学意义。结论:纳米银漱口水可作为慢性牙周炎非手术治疗的辅助手段。这项研究的结果表明,这两种漱口水显示出相同的有效性范围。这些结论得到了临床指标和生化指标的支持。
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Evaluation of the clinical parameters and volumetric analysis of gingival crevicular fluid for chlohexidine vying silver nanoparticle mouthwash the avant garde for chronic periodontitis
BACKGROUND: Oral cavity ecosystem represents a dynamic pattern. Scaling and root planing (SRP) is the gold standard approach for treatment of chronic periodontitis but used alone it may not be effective in removing periodontal pathogens from sites where access is poor. Although chlorhexidine is the most effective mouthwash against oral microorganisms, the side effects of long- term use suggest the need for an alternative. Hence, this study has been undertaken to know effectiveness of silver nanoparticle mouthwash with chlorhexidine mouthwash which is effective on common microorganisms of oral cavity. OBJECTIVE: To evaluate and compare the clinical and biochemical outcome of chlorhexidine (CHX) and silver nanoparticle as an adjunct to scaling and root planing (SRP) in patients with chronic periodontitis. METHODS: Ninety- two patients with generalized moderate to severe chronic periodontitis from the Dept. of Periodontology who fulfilled the inclusion and exclusion criteria were recruited for the study. In the experimental clinical trial, the clinical parameters likewise; Plaque index (PI), Gingival index (GI), probing depth (PD), clinical attachment loss (CAL) were assessed. The volumetric analysis of gingival crevicular fluid (GCF) levels were assessed at baseline and follow up visits. The IBM SPSS Statistics for Windows software, v. 20.0 (IBM Corp., Armonk, USA), was used. The data was numerically coded and entered into the program. Both the descriptive statistics and the inferential statistics were analyzed to compare the responses between the groups. RESULTS: The statistical analysis was carried out by descriptive as well as inferential statistics and both groups demonstrated significant intragroup reduction in PI, GI, PPD, CAL, GCF from baseline to 3 months follow-up. There were statistically significant intragroup differences between both the groups for all of the parameters. CONCLUSION: Silver nanoparticle mouthwash can be an alternative adjunct for non-surgical periodontal therapy in patients with chronic periodontitis. Results of this study indicated that both the mouth rinse demonstrated an equal range of effectiveness. These conclusions were supported by the clinical parameters and biochemical outcomes.
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来源期刊
Journal of Cellular Biotechnology
Journal of Cellular Biotechnology Biochemistry, Genetics and Molecular Biology-Biotechnology
CiteScore
0.70
自引率
0.00%
发文量
13
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