{"title":"尿中诱导晶体形成作为肿瘤分期的一个容易接近的指标?-翻译探索性研究","authors":"Norbert Laube , Florian Klein , Christian Fisang","doi":"10.1016/j.urine.2023.05.001","DOIUrl":null,"url":null,"abstract":"<div><p>Urinary concentrations of metabolic products associated with neoplasms can change the supersaturation and thus alter the potential of crystal formation in urine. This study examines the ability of the BONN-Risk-Index (BRI)-method of induced crystallization of Ca-oxalate in urine for monitoring the progression of (uro-)oncological diseases.</p><p>BRI was compared to tumor marker concentrations and imaging in patients with prostate cancer (PC) and patients with neuroendocrine tumors (NET). In NET, a correlation between BRI and the amount of bone metastases emerges. In PC, log<sub>2</sub>(BRI) and bone-specific alkaline-phosphatase inversely correlate with <em>r</em> = 0.71.</p><p>It was shown that BRI and the clinical picture promisingly correlate.</p></div>","PeriodicalId":75287,"journal":{"name":"Urine (Amsterdam, Netherlands)","volume":"5 ","pages":"Pages 34-39"},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Induced crystal formation in urine as an easily accessible indicator of tumor stage? – A translational explorative study\",\"authors\":\"Norbert Laube , Florian Klein , Christian Fisang\",\"doi\":\"10.1016/j.urine.2023.05.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Urinary concentrations of metabolic products associated with neoplasms can change the supersaturation and thus alter the potential of crystal formation in urine. This study examines the ability of the BONN-Risk-Index (BRI)-method of induced crystallization of Ca-oxalate in urine for monitoring the progression of (uro-)oncological diseases.</p><p>BRI was compared to tumor marker concentrations and imaging in patients with prostate cancer (PC) and patients with neuroendocrine tumors (NET). In NET, a correlation between BRI and the amount of bone metastases emerges. In PC, log<sub>2</sub>(BRI) and bone-specific alkaline-phosphatase inversely correlate with <em>r</em> = 0.71.</p><p>It was shown that BRI and the clinical picture promisingly correlate.</p></div>\",\"PeriodicalId\":75287,\"journal\":{\"name\":\"Urine (Amsterdam, Netherlands)\",\"volume\":\"5 \",\"pages\":\"Pages 34-39\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Urine (Amsterdam, Netherlands)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2590280623000049\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Urine (Amsterdam, Netherlands)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2590280623000049","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Induced crystal formation in urine as an easily accessible indicator of tumor stage? – A translational explorative study
Urinary concentrations of metabolic products associated with neoplasms can change the supersaturation and thus alter the potential of crystal formation in urine. This study examines the ability of the BONN-Risk-Index (BRI)-method of induced crystallization of Ca-oxalate in urine for monitoring the progression of (uro-)oncological diseases.
BRI was compared to tumor marker concentrations and imaging in patients with prostate cancer (PC) and patients with neuroendocrine tumors (NET). In NET, a correlation between BRI and the amount of bone metastases emerges. In PC, log2(BRI) and bone-specific alkaline-phosphatase inversely correlate with r = 0.71.
It was shown that BRI and the clinical picture promisingly correlate.
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