不同金纳米颗粒提取物对肾脏、肝脏功能及光催化应用的体内研究

Muhammad Isa Khan, Seemab Dildar, T. Iqbal, M. Shakil, M. Tahir, M. Zubair Rafique, Farooq Aziz, Sardar Bibi, M. Ijaz
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引用次数: 1

摘要

我们报道了一种新型的金纳米颗粒,通过绿色方法提取不同的水果提取物,由于其在不同的应用中具有多用途的特性而受到越来越多的关注。在本文中,成功地证明了GNPs合成的新鲜水果提取物石榴和花椒。采用SEM、EDX、uv -可见光谱等不同表征技术对样品进行光学性质、形貌和元素分析,通过ALT、AST、ALP、尿素、肌酐等检测GNPs的生物相容性,并研究制备的GNPs对肾脏和肝脏功能的影响。石榴果提取物制备的GNPs对家兔的影响大于花椒提取物制备的GNPs,但这种影响在3天后恢复正常,显示出其生物相容性。为了探索GNPs的光催化活性,还研究了光催化降解MB染料。结果表明,通过绿色合成路线制备的GNPs由于表面积大,在可见光区对MB染料的降解效果明显增强。这些颗粒由于其高表面能而在催化还原中更活跃,并在生物医学中作为生物相容性应用。
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In Vivo Study of Gold-Nanoparticles Using Different Extracts for kidney, liver function and Photocatalytic Application
We report novel gold nanoparticles by green method for different fruit extracts have gaining greater attention due to its versatile properties in different applications. In this article, GNPs synthesis is demonstrated successfully using fresh fruit extract of punica granatum and fragaria. The optical properties, morphology and elemental analysis of samples was done by using) different characterization techniques like SEM EDX and UV-Visible spectroscopy Biocompatibility of GNPs was determined by ALT, AST, ALP, Urea, Creatinine tests and also to investigate the effects of prepared GNPs on the kidney and liver functions. The GNPs prepared by fruit extract of punica granatum have more effects on the rabbits than GNPs prepared from fragaria but this effect normalizes after three days which shows its biocompatibility. To explore the photocatalytic activity of the GNPs the photocatalytic degradation of MB dye is also investigated. The results revealed that GNPs prepared through green synthesis route are found to be efficient enhancement in the degradation of MB dye in visible region due to large surface area. These particles were more active in catalytic reduction due to their high surface energy and in bio-medical applications as biocompatibility.
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