药物滥用导致体内代谢和表观遗传变化,这可能会增加疾病风险:左旋肉碱和营养物质的作用

Advances in drug and alcohol research Pub Date : 2023-01-18 eCollection Date: 2023-01-01 DOI:10.3389/adar.2023.10901
Mohamed Ashraf Virmani
{"title":"药物滥用导致体内代谢和表观遗传变化,这可能会增加疾病风险:左旋肉碱和营养物质的作用","authors":"Mohamed Ashraf Virmani","doi":"10.3389/adar.2023.10901","DOIUrl":null,"url":null,"abstract":"","PeriodicalId":72092,"journal":{"name":"Advances in drug and alcohol research","volume":" ","pages":"10901"},"PeriodicalIF":0.0000,"publicationDate":"2023-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10880790/pdf/","citationCount":"0","resultStr":"{\"title\":\"Drug abuse results in metabolic and epigenetic changes in body which may contribute to disease risk: Role of L-carnitine and nutrients.\",\"authors\":\"Mohamed Ashraf Virmani\",\"doi\":\"10.3389/adar.2023.10901\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\",\"PeriodicalId\":72092,\"journal\":{\"name\":\"Advances in drug and alcohol research\",\"volume\":\" \",\"pages\":\"10901\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10880790/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in drug and alcohol research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3389/adar.2023.10901\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in drug and alcohol research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3389/adar.2023.10901","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

药物滥用与重大健康风险相关(1,2)。研究还表明,昼夜节律、新陈代谢和成瘾之间存在重要联系(3-5)。一项研究分析了纹状体中棘神经元多巴胺D2受体(D2R)表达不足的小鼠的肝脏代谢组,发现与对照小鼠相比,肝脏昼夜节律代谢组发生了深刻变化(3)。进一步增加多巴胺水平的药物,如可卡因,会破坏肝脏的昼夜节律代谢谱。越来越明显的是,中枢神经系统和代谢之间存在着严格的沟通,而这种平衡可以被药物滥用所改变(图1)。药物滥用者失去平衡可能会增加代谢功能障碍的风险,从而可能导致成瘾恶化和可能的疾病状态,如代谢综合征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Drug abuse results in metabolic and epigenetic changes in body which may contribute to disease risk: Role of L-carnitine and nutrients.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Using health belief model constructs to understand the role of perceived disease threat and resilience in responding to COVID-19 among people who use drugs: a cluster analysis Risk factors for poor treatment outcomes among opioid-dependent clients taking methadone in Mombasa, Kenya Rethinking agrarian livelihoods affected by narcotic drug abuse on China’s Southeast Asian borders: a typological perspective Effects of repeated alcohol abstinence on within-subject prefrontal cortical gene expression in rhesus macaques. Book Review: Research ethics in the life sciences
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1