药物滥用导致体内代谢和表观遗传变化,这可能会增加疾病风险:左旋肉碱和营养物质的作用

Advances in drug and alcohol research Pub Date : 2023-01-18 eCollection Date: 2023-01-01 DOI:10.3389/adar.2023.10901
Mohamed Ashraf Virmani
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摘要

药物滥用与重大健康风险相关(1,2)。研究还表明,昼夜节律、新陈代谢和成瘾之间存在重要联系(3-5)。一项研究分析了纹状体中棘神经元多巴胺D2受体(D2R)表达不足的小鼠的肝脏代谢组,发现与对照小鼠相比,肝脏昼夜节律代谢组发生了深刻变化(3)。进一步增加多巴胺水平的药物,如可卡因,会破坏肝脏的昼夜节律代谢谱。越来越明显的是,中枢神经系统和代谢之间存在着严格的沟通,而这种平衡可以被药物滥用所改变(图1)。药物滥用者失去平衡可能会增加代谢功能障碍的风险,从而可能导致成瘾恶化和可能的疾病状态,如代谢综合征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Drug abuse results in metabolic and epigenetic changes in body which may contribute to disease risk: Role of L-carnitine and nutrients.
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