中性粒细胞减少伴菌血症发热儿童的细胞因子浓度动力学与长期发热的关系

Seongkoo Kim, S. Han, J. Kang
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引用次数: 0

摘要

导论:虽然中性粒细胞减少热(NF)患者在经经性抗生素治疗期间持续发热可能是由免疫反应失调引起的,但其与细胞因子浓度的关系很少被研究。本研究确定了小儿NF和菌血症患者的细胞因子浓度动力学,并评估了细胞因子浓度动力学对延长发烧的影响。方法:对10例伴有菌血症的NF患者,分别在NF发病第1天、第3天(第4天)和第7天(第8天)检测13种细胞因子浓度,并测定其动力学。对持续大于或小于3天的发热患者和持续小于3天的发热患者在每个采样日的每个细胞因子浓度的结果进行比较。结果:白细胞介素(IL)-6 (p < 0.001)和IL-10 (p = 0.001)浓度在第1天显著高于第4、8天。然而,在第1天增加的IL-6 (p = 1.000)和IL-10 (p = 1.000)浓度与延长发烧(大于或等于3天)无关。对于其他细胞因子,无论发烧持续时间如何,在第1、4和8天测量的浓度相似。结论:NF合并菌血症患者的持续发热与特定细胞因子浓度的持续升高无关。
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Association between cytokine concentration kinetics and prolonged fever in febrile neutropenic children with bacteremia
Introduction: Although prolonged fever in patients with neutropenic fever (NF) during empirical antibiotic therapy could be caused by dysregulated immune responses, its association with cytokine concentrations has rarely been investigated. This study determined the kinetics of cytokine concentrations in pediatric patients with NF and bacteremia and evaluated the impact of cytokine concentration kinetics on prolonged fever. Methods: Concentrations of 13 cytokines were measured on the initial day of NF (Day 1) and 3 days (Day 4) and 7 days (Day 8) later in 10 patients with NF with bacteremia, and their kinetics was determined. The results for each cytokine concentration on each sampling day were compared for patients with fever that lasted ⩾3 days and those with fever that lasted <3 days. Results: Interleukin (IL)-6 (p < .001) and IL-10 (p = .001) concentrations were significantly higher on Day 1 than on Days 4 and 8. However, the increased IL-6 (p = 1.000) and IL-10 (p = 1.000) concentrations on Day 1 were not associated with prolonged fever (⩾3 days). For other cytokines, the concentrations measured on Days 1, 4, and 8 were similar regardless of fever duration. Conclusion: Prolonged fever in patients with NF and bacteremia was not associated with a prolonged increase in a specific cytokine concentration.
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来源期刊
CiteScore
4.00
自引率
0.00%
发文量
88
审稿时长
15 weeks
期刊介绍: International Journal of Immunopathology and Pharmacology is an Open Access peer-reviewed journal publishing original papers describing research in the fields of immunology, pathology and pharmacology. The intention is that the journal should reflect both the experimental and clinical aspects of immunology as well as advances in the understanding of the pathology and pharmacology of the immune system.
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