Yana I Sakhno, Oleksandr V Radchenko, V. Saraev, Yuliia V. Shliapkina, Mariia B. Kaidash, Mariia O Shyshkina, S. Shishkina, V. Musatov, S. Desenko, V. Chebanov
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Temperature-Controlled Diastereoselective Doebner/Ugi Tandem Reaction
Novel peptidomimetics containing a pyrrolone fragment were synthesized by a tandem combination of Doebner and Ugi-type multicomponent reactions with controlled diastereoselectivity. This approach represents a convenient synthesis in the temperature range from 25 °C to 45 °C. In most cases, the new method allowed each diastereomer to be isolated separately.
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