{"title":"宿主代谢琥珀酸盐摄取与沙门氏菌毒力诱导的相关性","authors":"Y. Choi, Y. Koh","doi":"10.4167/JBV.2021.51.1.037","DOIUrl":null,"url":null,"abstract":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/ license/by-nc/3.0/). Accumulation of succinate promotes Salmonella pathogenic program during intracellular infection. Using RNA-seq, increased mRNA expression of the genes in pmrAB and Salmonella pathogenicity island2 (SPI-2) regulon is measured in succinate-containing medium. Furthermore, uptake of host metabolic succinate through DcuB transporter also induces program for Salmonella virulence. Thus, succinate is major factor of Salmonella enterica serovar Typhimurium (S.Tm) virulence induction.","PeriodicalId":39739,"journal":{"name":"Journal of Bacteriology and Virology","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Uptake of Host Metabolic Succinate Correlates with Salmonella Virulence Induction\",\"authors\":\"Y. Choi, Y. Koh\",\"doi\":\"10.4167/JBV.2021.51.1.037\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/ license/by-nc/3.0/). Accumulation of succinate promotes Salmonella pathogenic program during intracellular infection. Using RNA-seq, increased mRNA expression of the genes in pmrAB and Salmonella pathogenicity island2 (SPI-2) regulon is measured in succinate-containing medium. Furthermore, uptake of host metabolic succinate through DcuB transporter also induces program for Salmonella virulence. Thus, succinate is major factor of Salmonella enterica serovar Typhimurium (S.Tm) virulence induction.\",\"PeriodicalId\":39739,\"journal\":{\"name\":\"Journal of Bacteriology and Virology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Bacteriology and Virology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4167/JBV.2021.51.1.037\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Immunology and Microbiology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Bacteriology and Virology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4167/JBV.2021.51.1.037","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Immunology and Microbiology","Score":null,"Total":0}
Uptake of Host Metabolic Succinate Correlates with Salmonella Virulence Induction
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/ license/by-nc/3.0/). Accumulation of succinate promotes Salmonella pathogenic program during intracellular infection. Using RNA-seq, increased mRNA expression of the genes in pmrAB and Salmonella pathogenicity island2 (SPI-2) regulon is measured in succinate-containing medium. Furthermore, uptake of host metabolic succinate through DcuB transporter also induces program for Salmonella virulence. Thus, succinate is major factor of Salmonella enterica serovar Typhimurium (S.Tm) virulence induction.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
