基于肠道菌群的辐射肠损伤生物标志物研究进展

中华放射肿瘤学杂志 Pub Date : 2020-03-15 DOI:10.3760/CMA.J.ISSN.1004-4221.2020.03.018

Junjun Zhang, S. Cai, Yongqiang Yang, Junyan Li, Ye Tian

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引用次数: 0

摘要

近年来，肠道菌群及其代谢产物与肿瘤发生、炎症性肠病以及放射性肠道损伤之间的关系引起了研究人员的广泛关注。从核事故调查、动物模型实验和临床研究中积累的证据已经证明，肠道菌群及其代谢产物作为评估辐射剂量和放射性肠损伤严重程度的生物标志物的作用。本文综述了肠道菌群及其代谢产物与放射性肠损伤的关系，旨在为评估放射性肠损伤风险提供理论参考。关键词：肠道菌群；代谢物；辐射损伤；生物标志物

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Research progress on biomarkers for radiation-induced intestinal injury based on intestinal flora

Recently, the relationship between intestinal flora and its metabolites and tumorigenesis, inflammatory bowel diseasesas well as radiation-induced intestinal injury has captivated widespread attention from researchers. Accumulated evidence derived from nuclear accident investigation, animal model experiment and clinical research has proven the role of intestinal flora and its metabolites as the biomarkers to evaluate the radiation dose and severity of radiation-induced intestinal injury. This article reviews the relationship between intestinal flora and its metabolites and radiation-induced intestinal injury, aiming to provide theoretical reference for assessing the risk of radiation-induced intestinal injury. Key words: Intestinal flora; Metabolite; Radiation-induced injury; Biomarker

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来源期刊

中华放射肿瘤学杂志

自引率

0.00%

发文量

6375

期刊介绍： The Chinese Journal of Radiation Oncology is a national academic journal sponsored by the Chinese Medical Association. It was founded in 1992 and the title was written by Chen Minzhang, the former Minister of Health. Its predecessor was the Chinese Journal of Radiation Oncology, which was founded in 1987. The journal is an authoritative journal in the field of radiation oncology in my country. It focuses on clinical tumor radiotherapy, tumor radiation physics, tumor radiation biology, and thermal therapy. Its main readers are middle and senior clinical doctors and scientific researchers. It is now a monthly journal with a large 16-page format and 80 pages of text. For many years, it has adhered to the principle of combining theory with practice and combining improvement with popularization. It now has columns such as monographs, head and neck tumors (monographs), chest tumors (monographs), abdominal tumors (monographs), physics, technology, biology (monographs), reviews, and investigations and research.