Study of Genes Predisposition to The Development of Complications of Metabolic Syndrome

This review presents the most informative genes for the diagnosis of complications of metabolic syndrome. It is shown that the polymorphism G-455A (rs1800790) of the gene FGB, Glu298Asp (rs1799983) of the gene eNOS, G83A (rs2368564) of the gene REN are the most informative markers to as-sess the possibility of fatal complications of metabolic syndrome. Risk assessment and prognosis of the disease course is multifactorial, where the most formative method will be the assessment of the complex of many single-nucleotide polymorphisms of genes, since the presence of a synergistic interac-tion of genetic polymorphisms is important, when the presence of unfavorable variants of genes of several systems increases the probability of the disease and its more severe course.