α-Gal哺乳动物肉类过敏作为孤立性胃肠道症状的原因

Nathan E. Richards, T. Makin, Anna R. Smith, T. Platts-Mills, R. Richards, Jeffrey M. Wilson
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引用次数: 1

摘要

α-Gal哺乳动物肉类过敏通常表现为荨麻疹,伴或不伴胃肠道(GI)症状或过敏反应,但我们越来越多地注意到只有胃肠道症状的患者。在这里,我们描述了出现孤立胃肠道症状的患者,他们检测到α-Gal的IgE抗体,并报告在限制哺乳动物饮食后症状得到改善。一名胃肠病学家的40名患者和一家过敏诊所的35名患者被确定,腹痛、腹泻和恶心是最常见的症状。α - gal IgE水平低于先前描述的表现出典型过敏反应的患者队列。这一大型病例系列表明,α-Gal IgE是孤星蜱叮咬常见地区GI发病率的重要因素。GI-AGS的症状表现很容易与其他常见的胃肠道疾病混淆,α-Gal IgE水平通常低于经典AGS患者。
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The α-Gal mammalian meat allergy as a cause of isolated gastrointestinal symptoms
The α-Gal mammalian meat allergy classically presents with urticaria, with or without gastrointestinal (GI) symptoms or anaphylaxis, but increasingly we are aware of patients with only GI symptoms. Here we describe patients presenting with isolated GI symptoms who had detectable IgE antibodies to α-Gal and reported symptom improvement on a mammal-restricted diet. Forty patients in the practice of a single gastroenterologist, and 35 patients in one allergy clinic were identified, with abdominal pain, diarrhea, and nausea the most common symptoms. Alpha-Gal IgE levels were lower than in a previously described cohort of patients who exhibited classic allergic reactions. This large case series suggests that α-Gal IgE is an important contributor to GI morbidity in areas where lone star tick bites are common. Symptom presentations in GI-AGS can be easily confused with other common GI conditions, and α-Gal IgE levels are often lower than those in patients with classic AGS.
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