{"title":"抗纤溶剂用于预防产后出血","authors":"Anne-Sophie Bouthors , Sixtine Gilliot , David Faraoni , Loic Sentilhes","doi":"10.1016/j.tru.2021.100089","DOIUrl":null,"url":null,"abstract":"<div><p>Acute obstetric coagulopathy secondary to postpartum hemorrhage (PPH) is associated with poor outcome. There is evidence that Tranexamic Acid (TA), an antifibrinolytic drug, is an efficient tool of patient blood management in association with uterotonics to reduce mortality due to postpartum hemorrhage (PPH). Recent trials investigated its preventive administration before PPH. This review summarizes their major results and introduces the ongoing debate on a systematic prophylaxis of coagulopathy before PPH occurs.</p></div>","PeriodicalId":34401,"journal":{"name":"Thrombosis Update","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666572721000584/pdfft?md5=8da34bc21b00434a9a399026df2a0daf&pid=1-s2.0-S2666572721000584-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Antifibrinolytic agents for the prevention of postpartum hemorrhage\",\"authors\":\"Anne-Sophie Bouthors , Sixtine Gilliot , David Faraoni , Loic Sentilhes\",\"doi\":\"10.1016/j.tru.2021.100089\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Acute obstetric coagulopathy secondary to postpartum hemorrhage (PPH) is associated with poor outcome. There is evidence that Tranexamic Acid (TA), an antifibrinolytic drug, is an efficient tool of patient blood management in association with uterotonics to reduce mortality due to postpartum hemorrhage (PPH). Recent trials investigated its preventive administration before PPH. This review summarizes their major results and introduces the ongoing debate on a systematic prophylaxis of coagulopathy before PPH occurs.</p></div>\",\"PeriodicalId\":34401,\"journal\":{\"name\":\"Thrombosis Update\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2666572721000584/pdfft?md5=8da34bc21b00434a9a399026df2a0daf&pid=1-s2.0-S2666572721000584-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Thrombosis Update\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666572721000584\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Thrombosis Update","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666572721000584","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
Antifibrinolytic agents for the prevention of postpartum hemorrhage
Acute obstetric coagulopathy secondary to postpartum hemorrhage (PPH) is associated with poor outcome. There is evidence that Tranexamic Acid (TA), an antifibrinolytic drug, is an efficient tool of patient blood management in association with uterotonics to reduce mortality due to postpartum hemorrhage (PPH). Recent trials investigated its preventive administration before PPH. This review summarizes their major results and introduces the ongoing debate on a systematic prophylaxis of coagulopathy before PPH occurs.
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