Effects of enteral nutrition on acute inflammation, immune cells and lipid metabolism in patients after pancreaticoduodenectomy

Objective To study the effects of different parenteral nutrition on acute inflammatory response, immune cells and lipid metabolism in patients after pancreaticoduodenectomy. Methods Eighty patients after pancreaticoduodenectomy were divided into study group and control group, with 40 cases in each group. Structural fat emulsion was used in study group and medium/long chain fat emulsion in control group. The changes of acute inflammation, immune cells and lipid metabolism were compared between the two groups. Results (1)The levels of C-reactive protein (CRP) and serum prostaglandin E2 (PGE2) in the two groups were significantly higher on the first day after operation than those before operation. The difference between the two groups was statistically significant (P<0.05). The level of CRP and PGE2 decreased to the preoperative level on the seventh day after operation, but the decline rate in the study group was significantly faster than that in the control group (P<0.05). (2)The levels of CD3+ , CD4+ , CD8+ , CD4+ /CD8+ in the study group were significantly higher than those in the control group (P<0.05). (3)After 3-7 days of intravenous parenteral nutrition infusion, the blood lipid level was significantly lower in study group (P<0.05). Conclusion Structural fat emulsion alleviates the inflammatory reaction in patients after pancreaticoduodenectomy, promotes the recovery of immunity, significantly reduces the level of blood lipids. Key words: Pancreaticoduodenectomy; Parenteral nutrition; C-reactive protein