NLRP3炎症小体活性增强及其在甲型流感病毒性肺炎中的促炎作用

IF 2.1 4区医学 Q3 VIROLOGY Future Virology Pub Date : 2022-12-01 DOI:10.2217/fvl-2021-0025

Xiaohan Shi, Benquan Wu, Junxian Chen, Jinmei Luo, Mei Li, Zhenyou Jiang, Yunfeng Shi

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引用次数: 0

摘要

目的：研究NLRP3炎症小体的活性及其在甲型流感病毒（IAV）感染后1周诱导重症肺炎中的作用。材料与方法：检测IAV刺激的小鼠巨噬细胞中NLRP3、胱天蛋白酶-1和IL-1β的表达水平。并对小鼠病毒性肺炎的严重程度进行了探讨。结果与结论：尽管NLRP3的表达存在差异，但在感染IAV后1周，NLRP3炎症小体的活性增强，更严重的病毒性肺炎与血清中的IL-1β有关。由此推断，在IAV感染后1周，NLRP3炎症小体活性的增强以非NLRP3依赖的方式诱导IL-1β的表达增强和严重肺炎。

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Enhanced activity of NLRP3 inflammasome and its proinflammatory effect in influenza A viral pneumonia

Aim: The aim of this study was to investigate the activity of NLRP3 inflammasome and its effect on inducing severe pneumonia 1 week after influenza A virus (IAV) infection. Materials & methods: The expression levels of NLRP3, caspase-1 and IL-1β were assessed in murine macrophages stimulated with IAV. And the severity of viral pneumonia in mice was explored. Results & conclusion: The data showed that although the expression of NLRP3 diverged, activity of NLRP3 inflammasome was enhanced 1 week after IAV infection, and more severe viral pneumonia was associated with IL-1β in serum. It infers that enhanced activity of NLRP3 inflammasome induces augmented expression of IL-1β and severe pneumonia in a NLRP3-independent way, 1 week after IAV infection.

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来源期刊

Future Virology 医学-病毒学

CiteScore

4.00

自引率

3.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Future Virology is a peer-reviewed journal that delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this ever-expanding area of research. It is an interdisciplinary forum for all scientists working in the field today.